| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM50560035 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2071148 (CHEMBL4726682) |
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| IC50 | 980±n/a nM |
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| Citation |  Koutsopoulos, K; Lavrentaki, V; Antoniou, I; Kousaxidis, A; Lefkopoulou, M; Tsantili-Kakoulidou, A; Kovacikova, L; Stefek, M; Nicolaou, I Design synthesis and evaluation of novel aldose reductase inhibitors: The case of indolyl-sulfonyl-phenols. Bioorg Med Chem28:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35797.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1512484 |
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| Residue: | 316 |
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| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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| BDBM50560035 |
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| n/a |
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| Name | BDBM50560035 |
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| Synonyms: | CHEMBL4784848 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10FNO3S |
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| Mol. Mass. | 291.298 |
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| SMILES | Oc1ccc(cc1F)S(=O)(=O)n1ccc2ccccc12 |
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| Structure | 
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