| Reaction Details |
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 | Report a problem with these data |
| Target | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase |
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| Ligand | BDBM50561669 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2075686 (CHEMBL4731220) |
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| IC50 | 0.400000±n/a nM |
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| Citation |  Thurairatnam, S; Lim, S; Barker, RH; Choi-Sledeski, YM; Hirth, BH; Jiang, J; Macor, JE; Makino, E; Maniar, S; Musick, K; Pribish, JR; Munson, M Brain Penetrable Inhibitors of Ceramide Galactosyltransferase for the Treatment of Lysosomal Storage Disorders. ACS Med Chem Lett11:2010-2016 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 2-hydroxyacylsphingosine 1-beta-galactosyltransferase |
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| Name: | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase |
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| Synonyms: | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase | 2.4.1.47 | CGT | CGT_HUMAN | Ceramide UDP-galactosyltransferase | Cerebroside synthase | UDP-galactose-ceramide galactosyltransferase | UGT4 | UGT8 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61470.74 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_120191 |
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| Residue: | 541 |
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| Sequence: | MKSYTPYFILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGR
DIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGN
HALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEF
NSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLW
MLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYL
SEDIANKLAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGG
LNSIFETIYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNP
SYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFV
LLLGAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKV
K
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| BDBM50561669 |
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| n/a |
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| Name | BDBM50561669 |
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| Synonyms: | CHEMBL4787939 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25F3N4O3S |
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| Mol. Mass. | 458.498 |
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| SMILES | CC[C@H](C)NC(=O)OC1CCN(CC1)c1cc(c2scc(C(=O)NC)c2n1)C(F)(F)F |r| |
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| Structure | 
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