Reaction Details |
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Target | Histone deacetylase 3 |
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Ligand | BDBM375724 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2076391 (CHEMBL4731925) |
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IC50 | 80±n/a nM |
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Citation | Liu, J; Yu, Y; Kelly, J; Sha, D; Alhassan, AB; Yu, W; Maletic, MM; Duffy, JL; Klein, DJ; Holloway, MK; Carroll, S; Howell, BJ; Barnard, RJO; Wolkenberg, S; Kozlowski, JA Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group. ACS Med Chem Lett11:2476-2483 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 3 |
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Name: | Histone deacetylase 3 |
Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
Type: | Enzyme |
Mol. Mass.: | 48829.55 |
Organism: | Homo sapiens (Human) |
Description: | O15379 |
Residue: | 428 |
Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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BDBM375724 |
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n/a |
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Name | BDBM375724 |
Synonyms: | US10301323, Compound D1 | US9908899, Compound D1 |
Type | Small organic molecule |
Emp. Form. | C21H20N4O |
Mol. Mass. | 344.4097 |
SMILES | Nc1ccccc1NC(=O)\C=C\c1cnn(C\C=C\c2ccccc2)c1 |
Structure |
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