| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polycomb protein EED |
|---|
| Ligand | BDBM50282164 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2079572 (CHEMBL4735363) |
|---|
| IC50 | 14800±n/a nM |
|---|
| Citation |  Martin, MC; Zeng, G; Yu, J; Schiltz, GE Small Molecule Approaches for Targeting the Polycomb Repressive Complex 2 (PRC2) in Cancer. J Med Chem63:15344-15370 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polycomb protein EED |
|---|
| Name: | Polycomb protein EED |
|---|
| Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 50201.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75530 |
|---|
| Residue: | 441 |
|---|
| Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
|
|
|
|---|
| BDBM50282164 |
|---|
| n/a |
|---|
| Name | BDBM50282164 |
|---|
| Synonyms: | CHEMBL4164708 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C33H57N10O7 |
|---|
| Mol. Mass. | 705.8679 |
|---|
| SMILES | COC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCC[N+](C)(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCC(N)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
