| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM50563408 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2082245 (CHEMBL4738036) |
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| IC50 | 9.7±n/a nM |
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| Citation |  Zhang, X; Chen, H; Lei, Y; Zhang, X; Xu, L; Liu, W; Fan, Z; Ma, Z; Yin, Z; Li, L; Zhu, C; Ma, B Multifunctional agents based on benzoxazolone as promising therapeutic drugs for diabetic nephropathy. Eur J Med Chem215:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35797.87 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1512484 |
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| Residue: | 316 |
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| Sequence: | MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQ
EKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGP
DYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKP
AVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAK
YNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCA
LMSCAKHKDYPFHAEV
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| BDBM50563408 |
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| n/a |
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| Name | BDBM50563408 |
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| Synonyms: | CHEMBL4743085 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10F3NO4 |
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| Mol. Mass. | 337.2501 |
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| SMILES | OC(=O)Cn1c2cccc(-c3ccc(cc3)C(F)(F)F)c2oc1=O |
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| Structure | 
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