Reaction Details |
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Target | Chloroquine resistance transporter |
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Ligand | BDBM50563442 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2082532 (CHEMBL4738323) |
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IC50 | 15600±n/a nM |
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Citation | Relitti, N; Federico, S; Pozzetti, L; Butini, S; Lamponi, S; Taramelli, D; D'Alessandro, S; Martin, RE; Shafik, SH; Summers, RL; Babij, SK; Habluetzel, A; Tapanelli, S; Caldelari, R; Gemma, S; Campiani, G Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity. Eur J Med Chem215:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Chloroquine resistance transporter |
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Name: | Chloroquine resistance transporter |
Synonyms: | CRT | CRT_PLAFA | PfCRT |
Type: | PROTEIN |
Mol. Mass.: | 48687.29 |
Organism: | Plasmodium falciparum |
Description: | ChEMBL_1364181 |
Residue: | 424 |
Sequence: | MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIF
IYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSK
ERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYH
LYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKI
DILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVEN
CGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAY
YFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDS
IITQ
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BDBM50563442 |
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n/a |
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Name | BDBM50563442 |
Synonyms: | CHEMBL4754685 |
Type | Small organic molecule |
Emp. Form. | C50H42Cl4N6 |
Mol. Mass. | 868.721 |
SMILES | Clc1ccc(cc1)C(Nc1ccnc2cc(Cl)ccc12)c1ccc(CN2CCN(Cc3ccc(cc3)C(Nc3ccnc4cc(Cl)ccc34)c3cccc(Cl)c3)CC2)cc1 |
Structure |
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