Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50563645 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2083407 (CHEMBL4739198) | ||
| IC50 | 63±n/a nM | ||
| Citation |  Nissink, JWM; Bazzaz, S; Blackett, C; Clark, MA; Collingwood, O; Disch, JS; Gikunju, D; Goldberg, K; Guilinger, JP; Hardaker, E; Hennessy, EJ; Jetson, R; Keefe, AD; McCoull, W; McMurray, L; Olszewski, A; Overman, R; Pflug, A; Preston, M; Rawlins, PB; Rivers, E; Schimpl, M; Smith, P; Truman, C; Underwood, E; Warwicker, J; Winter-Holt, J; Woodcock, S; Zhang, Y Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J Med Chem64:3165-3184 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM50563645 | |||
| n/a | |||
| Name | BDBM50563645 | ||
| Synonyms: | CHEMBL4747462 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H18F6N6O2S | ||
| Mol. Mass. | 532.462 | ||
| SMILES | CNC(=O)c1sc(nc1C(F)(F)F)N1CC2CC1(CNC(=O)c1c[nH]c3ncc(cc13)C(F)(F)F)C2 |(69.05,-6.83,;67.51,-6.82,;66.74,-8.15,;67.5,-9.49,;65.2,-8.15,;64.3,-6.9,;62.82,-7.37,;62.82,-8.91,;64.29,-9.39,;64.75,-10.85,;66.29,-10.85,;65.52,-12.18,;63.72,-12,;61.58,-6.46,;61.59,-4.92,;60.12,-4.44,;59.21,-5.68,;60.12,-6.93,;59.64,-8.39,;58.13,-8.71,;57.1,-7.56,;57.58,-6.1,;55.59,-7.87,;54.97,-9.27,;53.44,-9.11,;53.13,-7.6,;51.79,-6.84,;51.79,-5.3,;53.12,-4.53,;54.45,-5.29,;54.46,-6.84,;53.11,-2.98,;51.57,-2.98,;52.34,-1.65,;54.45,-2.21,;60.52,-5.92,)| | ||
| Structure | 
| ||