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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50563646 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2083407 (CHEMBL4739198) | ||
| IC50 | 25±n/a nM | ||
| Citation |  Nissink, JWM; Bazzaz, S; Blackett, C; Clark, MA; Collingwood, O; Disch, JS; Gikunju, D; Goldberg, K; Guilinger, JP; Hardaker, E; Hennessy, EJ; Jetson, R; Keefe, AD; McCoull, W; McMurray, L; Olszewski, A; Overman, R; Pflug, A; Preston, M; Rawlins, PB; Rivers, E; Schimpl, M; Smith, P; Truman, C; Underwood, E; Warwicker, J; Winter-Holt, J; Woodcock, S; Zhang, Y Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J Med Chem64:3165-3184 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
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| BDBM50563646 | |||
| n/a | |||
| Name | BDBM50563646 | ||
| Synonyms: | CHEMBL4740965 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H19F3N6O2S | ||
| Mol. Mass. | 464.464 | ||
| SMILES | CNC(=O)c1sc(nc1C(F)(F)F)N1CC2CC1(CNC(=O)c1c[nH]c3ncccc13)C2 |(19.99,-20.98,;18.45,-20.98,;17.67,-22.31,;18.44,-23.64,;16.13,-22.3,;15.23,-21.05,;13.76,-21.53,;13.76,-23.06,;15.22,-23.55,;15.69,-25.01,;17.23,-25.01,;16.46,-26.34,;14.66,-26.15,;12.52,-20.62,;12.52,-19.08,;11.06,-18.59,;10.15,-19.84,;11.06,-21.09,;10.57,-22.55,;9.07,-22.86,;8.04,-21.72,;8.52,-20.25,;6.53,-22.03,;5.91,-23.42,;4.38,-23.26,;4.06,-21.76,;2.73,-21,;2.73,-19.45,;4.06,-18.68,;5.39,-19.45,;5.4,-21,;11.46,-20.07,)| | ||
| Structure | 
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