Reaction Details | |||
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Target | Receptor-type tyrosine-protein kinase FLT3 | ||
Ligand | BDBM50563644 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_2083409 (CHEMBL4739200) | ||
IC50 | 1585±n/a nM | ||
Citation | Nissink, JWM; Bazzaz, S; Blackett, C; Clark, MA; Collingwood, O; Disch, JS; Gikunju, D; Goldberg, K; Guilinger, JP; Hardaker, E; Hennessy, EJ; Jetson, R; Keefe, AD; McCoull, W; McMurray, L; Olszewski, A; Overman, R; Pflug, A; Preston, M; Rawlins, PB; Rivers, E; Schimpl, M; Smith, P; Truman, C; Underwood, E; Warwicker, J; Winter-Holt, J; Woodcock, S; Zhang, Y Generating Selective Leads for Mer Kinase Inhibitors-Example of a Comprehensive Lead-Generation Strategy. J Med Chem64:3165-3184 (2021) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Receptor-type tyrosine-protein kinase FLT3 | |||
Name: | Receptor-type tyrosine-protein kinase FLT3 | ||
Synonyms: | CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 112888.62 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P36888 | ||
Residue: | 993 | ||
Sequence: |
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BDBM50563644 | |||
n/a | |||
Name | BDBM50563644 | ||
Synonyms: | CHEMBL4782810 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H21F3N6O2S | ||
Mol. Mass. | 478.491 | ||
SMILES | CNC(=O)c1sc(nc1C(F)(F)F)N1CC2CC1(CNC(=O)c1c[nH]c3ncc(C)cc13)C2 |(45.05,-5.8,;43.51,-5.8,;42.74,-7.13,;43.5,-8.46,;41.2,-7.12,;40.3,-5.87,;38.82,-6.34,;38.82,-7.88,;40.29,-8.36,;40.75,-9.82,;42.29,-9.82,;41.52,-11.16,;39.72,-10.97,;37.58,-5.43,;37.59,-3.89,;36.13,-3.41,;35.22,-4.66,;36.12,-5.9,;35.64,-7.37,;34.13,-7.68,;33.1,-6.53,;33.58,-5.07,;31.6,-6.85,;30.97,-8.24,;29.44,-8.08,;29.13,-6.58,;27.79,-5.81,;27.79,-4.27,;29.12,-3.5,;29.11,-1.96,;30.45,-4.26,;30.46,-5.81,;36.52,-4.89,)| | ||
Structure |