| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Monoglyceride lipase |
|---|
| Ligand | BDBM50065646 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2084323 (CHEMBL4765586) |
|---|
| IC50 | <0.400000±n/a nM |
|---|
| Citation |  Afzal, O; Akhtar, MS; Kumar, S; Ali, MR; Jaggi, M; Bawa, S Hit to lead optimization of a series of N-[4-(1,3-benzothiazol-2-yl)phenyl]acetamides as monoacylglycerol lipase inhibitors with potential anticancer activity. Eur J Med Chem121:318-330 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Monoglyceride lipase |
|---|
| Name: | Monoglyceride lipase |
|---|
| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
|---|
| Type: | Hydrolase |
|---|
| Mol. Mass.: | 33264.56 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
|---|
| Residue: | 303 |
|---|
| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
|
|
|
|---|
| BDBM50065646 |
|---|
| n/a |
|---|
| Name | BDBM50065646 |
|---|
| Synonyms: | CHEMBL3087181 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H22N4O5 |
|---|
| Mol. Mass. | 434.4446 |
|---|
| SMILES | O=C(N1CCC(CC1)C(c1ccc2OCOc2c1)c1ccc2OCOc2c1)n1cncn1 |
|---|
| Structure | 
|
|---|
Search and Browse
