Reaction Details |
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Target | Cholesteryl ester transfer protein |
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Ligand | BDBM50128136 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_216899 (CHEMBL815632) |
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IC50 | 70.0±n/a nM |
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Citation | Reinhard, EJ; Wang, JL; Durley, RC; Fobian, YM; Grapperhaus, ML; Hickory, BS; Massa, MA; Norton, MB; Promo, MA; Tollefson, MB; Vernier, WF; Connolly, DT; Witherbee, BJ; Melton, MA; Regina, KJ; Smith, ME; Sikorski, JA Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein. J Med Chem46:2152-68 (2003) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cholesteryl ester transfer protein |
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Name: | Cholesteryl ester transfer protein |
Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
Type: | Enzyme |
Mol. Mass.: | 54751.53 |
Organism: | Homo sapiens (Human) |
Description: | P11597 |
Residue: | 493 |
Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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BDBM50128136 |
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n/a |
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Name | BDBM50128136 |
Synonyms: | 3-((3-(3,5-dimethylphenoxy)phenyl)(3-(1,1,2,2-tetrafluoroethoxy)benzyl)amino)-1,1,1-trifluoropropan-2-ol | 3-{[3-(3,5-Dimethyl-phenoxy)-phenyl]-[3-(1,1,2,2-tetrafluoro-ethoxy)-benzyl]-amino}-1,1,1-trifluoro-propan-2-ol | CHEMBL433103 |
Type | Small organic molecule |
Emp. Form. | C26H24F7NO3 |
Mol. Mass. | 531.4625 |
SMILES | Cc1cc(C)cc(Oc2cccc(c2)N(CC(O)C(F)(F)F)Cc2cccc(OC(F)(F)C(F)F)c2)c1 |
Structure |
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