Reaction Details |
| Report a problem with these data |
Target | Cholesteryl ester transfer protein |
---|
Ligand | BDBM50128165 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_216899 (CHEMBL815632) |
---|
IC50 | 200±n/a nM |
---|
Citation | Reinhard, EJ; Wang, JL; Durley, RC; Fobian, YM; Grapperhaus, ML; Hickory, BS; Massa, MA; Norton, MB; Promo, MA; Tollefson, MB; Vernier, WF; Connolly, DT; Witherbee, BJ; Melton, MA; Regina, KJ; Smith, ME; Sikorski, JA Discovery of a simple picomolar inhibitor of cholesteryl ester transfer protein. J Med Chem46:2152-68 (2003) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cholesteryl ester transfer protein |
---|
Name: | Cholesteryl ester transfer protein |
Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
Type: | Enzyme |
Mol. Mass.: | 54751.53 |
Organism: | Homo sapiens (Human) |
Description: | P11597 |
Residue: | 493 |
Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
|
|
|
BDBM50128165 |
---|
n/a |
---|
Name | BDBM50128165 |
Synonyms: | 1,1,1-Trifluoro-3-{[3-(1,1,2,2-tetrafluoro-ethoxy)-benzyl]-[3-(3-trifluoromethyl-phenoxy)-phenyl]-amino}-propan-2-ol | 1,1,1-trifluoro-3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(3-(trifluoromethyl)phenoxy)phenyl)amino)propan-2-ol | 3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-(3-(trifluoromethyl)phenoxy)phenyl)amino)-1,1,1-trifluoropropan-2-ol | CHEMBL68632 |
Type | Small organic molecule |
Emp. Form. | C25H19F10NO3 |
Mol. Mass. | 571.4073 |
SMILES | OC(CN(Cc1cccc(OC(F)(F)C(F)F)c1)c1cccc(Oc2cccc(c2)C(F)(F)F)c1)C(F)(F)F |
Structure |
|