| Reaction Details |
|---|
 | Report a problem with these data |
| Target | BDNF/NT-3 growth factors receptor |
|---|
| Ligand | BDBM50564363 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2087535 (CHEMBL4768798) |
|---|
| IC50 | 2.0±n/a nM |
|---|
| Citation |  Jeong, P; Moon, Y; Lee, JH; Lee, SD; Park, J; Lee, J; Kim, J; Lee, HJ; Kim, NY; Choi, J; Heo, JD; Shin, JE; Park, HW; Kim, YG; Han, SY; Kim, YC Discovery of orally active indirubin-3'-oxime derivatives as potent type 1 FLT3 inhibitors for acute myeloid leukemia. Eur J Med Chem195:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| BDNF/NT-3 growth factors receptor |
|---|
| Name: | BDNF/NT-3 growth factors receptor |
|---|
| Synonyms: | GP145-TrkB | NTRK1/NTRK2 | NTRK2 | NTRK2_HUMAN | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B | Tropomyosin-related kinase B (TRKB) | Tyrosine kinase receptor B (Trk-B) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 91996.87 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16620 |
|---|
| Residue: | 822 |
|---|
| Sequence: | MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEP
NSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHI
NFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNES
SKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHM
NETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH
WCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYT
LIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPST
DVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASP
LHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVL
KRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHI
VKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQI
AAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWM
PPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQ
EVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
|
|
|
|---|
| BDBM50564363 |
|---|
| n/a |
|---|
| Name | BDBM50564363 |
|---|
| Synonyms: | CHEMBL4791998 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H23ClFN5O2 |
|---|
| Mol. Mass. | 443.902 |
|---|
| SMILES | Cl.Fc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\OCCN3CCNCC3)c2c1 |
|---|
| Structure | 
|
|---|
Search and Browse
