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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Dipeptidyl peptidase 4 | ||
| Ligand | BDBM50129926 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_53208 (CHEMBL664029) | ||
| IC50 | 18±n/a nM | ||
| Citation |  Villhauer, EB; Brinkman, JA; Naderi, GB; Burkey, BF; Dunning, BE; Prasad, K; Mangold, BL; Russell, ME; Hughes, TE 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem46:2774-89 (2003) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Dipeptidyl peptidase 4 | |||
| Name: | Dipeptidyl peptidase 4 | ||
| Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 88271.01 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P27487 | ||
| Residue: | 766 | ||
| Sequence: |
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| BDBM50129926 | |||
| n/a | |||
| Name | BDBM50129926 | ||
| Synonyms: | CHEMBL92021 | Cyclohexanecarboxylic acid {4-[2-(2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-cyclohexyl}-amide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H32N4O2 | ||
| Mol. Mass. | 360.4937 | ||
| SMILES | O=C(CNC1CC[C@@H](CC1)NC(=O)C1CCCCC1)N1CCC[C@H]1C#N |wD:7.10,23.26,(-.06,4.36,;.26,2.86,;-.88,1.81,;-2.35,2.29,;-3.49,1.25,;-3.49,-.29,;-4.82,-1.06,;-6.14,-.29,;-6.14,1.25,;-4.82,2.02,;-7.48,-1.06,;-7.51,-2.6,;-6.16,-3.37,;-8.84,-3.36,;-8.84,-4.88,;-10.19,-5.65,;-11.49,-4.86,;-11.49,-3.32,;-10.17,-2.57,;1.73,2.38,;2.22,.9,;3.76,.9,;4.25,2.38,;2.99,3.28,;3.74,4.64,;4.51,5.99,)| | ||
| Structure | 
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