Reaction Details |
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Target | Apelin receptor |
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Ligand | BDBM50566282 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2099903 (CHEMBL4808299) |
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Ki | 0.070000±n/a nM |
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Citation | Trân, K; Van Den Hauwe, R; Sainsily, X; Couvineau, P; Côté, J; Simard, L; Echevarria, M; Murza, A; Serre, A; Théroux, L; Saibi, S; Haroune, L; Longpré, JM; Lesur, O; Auger-Messier, M; Spino, C; Bouvier, M; Sarret, P; Ballet, S; Marsault, É Constraining the Side Chain of C-Terminal Amino Acids in Apelin-13 Greatly Increases Affinity, Modulates Signaling, and Improves the Pharmacokinetic Profile. J Med Chem64:5345-5364 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Apelin receptor |
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Name: | Apelin receptor |
Synonyms: | AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 42664.06 |
Organism: | Homo sapiens (Human) |
Description: | P35414 |
Residue: | 380 |
Sequence: | MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD
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BDBM50566282 |
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n/a |
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Name | BDBM50566282 |
Synonyms: | CHEMBL4867453 |
Type | Small organic molecule |
Emp. Form. | C71H110N22O16 |
Mol. Mass. | 1527.7709 |
SMILES | CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N1Cc2ccccc2C[C@@H]1C(O)=O |r| |
Structure |
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