Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Suppressor of tumorigenicity 14 protein (Homo sapiens (Human)) | BDBM50420334 (CHEMBL2086421) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tight binding inhibition of human matriptase expressed in Drosophila melanogaster S2 cells using Boc-QAR-AMC as substrate incubated for 15 mins prior... | ACS Med Chem Lett 3: 530-534 (2012) Article DOI: 10.1021/ml3000534 BindingDB Entry DOI: 10.7270/Q2DN469X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein [596-855] (Homo sapiens (Human)) | BDBM236490 (US9365853, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0110 | -62.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
TBA US Patent | Assay Description Enzymatic assays were performed in the following reaction buffer: 50 mM HEPES, pH 7.4 containing 500 μg/ml bovine serum albumin. Enzyme activiti... | US Patent US9365853 (2016) BindingDB Entry DOI: 10.7270/Q28W3C6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transmembrane protease serine 6 (Homo sapiens (Human)) | BDBM525149 (US10988505, Comparative #1) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Enzymatic assays and Ki determination were performed at room temperature in an assay buffer containing 50 mM Tris-HCl, 150 mM NaCl and 500 μg/mL... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X351MD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50078007 (CHEMBL3417384) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr b... | J Med Chem 58: 2431-40 (2015) Article DOI: 10.1021/jm501916k BindingDB Entry DOI: 10.7270/Q21V5GNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566289 (CHEMBL4878158) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566283 (CHEMBL4876632) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein (Homo sapiens (Human)) | BDBM50032696 (CHEMBL3354674) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Inhibition of human recombinant matriptase using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis | J Med Chem 57: 10198-204 (2014) Article DOI: 10.1021/jm5015633 BindingDB Entry DOI: 10.7270/Q2DJ5H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566282 (CHEMBL4867453) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566303 (CHEMBL4867913) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566306 (CHEMBL4876492) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566310 (CHEMBL4855178) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein [596-855] (Homo sapiens (Human)) | BDBM236493 (US10988505, Comparative #2 | US9365853, 4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0880 | -57.4 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
TBA US Patent | Assay Description Enzymatic assays were performed in the following reaction buffer: 50 mM HEPES, pH 7.4 containing 500 μg/ml bovine serum albumin. Enzyme activiti... | US Patent US9365853 (2016) BindingDB Entry DOI: 10.7270/Q28W3C6F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein (Homo sapiens (Human)) | BDBM50420336 (CHEMBL2089123) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tight binding inhibition of human matriptase expressed in Drosophila melanogaster S2 cells using Boc-QAR-AMC as substrate incubated for 15 mins prior... | ACS Med Chem Lett 3: 530-534 (2012) Article DOI: 10.1021/ml3000534 BindingDB Entry DOI: 10.7270/Q2DN469X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transmembrane protease serine 6 (Homo sapiens (Human)) | BDBM236493 (US10988505, Comparative #2 | US9365853, 4) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Enzymatic assays and Ki determination were performed at room temperature in an assay buffer containing 50 mM Tris-HCl, 150 mM NaCl and 500 μg/mL... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X351MD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566304 (CHEMBL4858171) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50400807 (CHEMBL2204324) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite£ de Sherbrooke Curated by ChEMBL | Assay Description Inhibition of thrombin | J Med Chem 54: 1961-2004 (2011) Article DOI: 10.1021/jm1012374 BindingDB Entry DOI: 10.7270/Q28C9XDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein (Homo sapiens (Human)) | BDBM50032702 (CHEMBL3352840) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0920 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Inhibition of human recombinant matriptase using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis | J Med Chem 57: 10198-204 (2014) Article DOI: 10.1021/jm5015633 BindingDB Entry DOI: 10.7270/Q2DJ5H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50244625 (CHEMBL4076049) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]-[Nle75, Tyr77] Pyr1-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cell membranes after 1 hr by gamma-counti... | J Med Chem 61: 2266-2277 (2018) Article DOI: 10.1021/acs.jmedchem.7b01353 BindingDB Entry DOI: 10.7270/Q27M0BC2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566301 (CHEMBL4876350) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566296 (CHEMBL4879304) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transmembrane protease serine 6 (Homo sapiens (Human)) | BDBM50032698 (CHEMBL3354676 | N-0130) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li... | Citation and Details Article DOI: 10.1038/s41586-022-04661-w BindingDB Entry DOI: 10.7270/Q2NP27M4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transmembrane protease serine 6 (Homo sapiens (Human)) | BDBM525151 (US10988505, Example 1) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.134 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Enzymatic assays and Ki determination were performed at room temperature in an assay buffer containing 50 mM Tris-HCl, 150 mM NaCl and 500 μg/mL... | Citation and Details BindingDB Entry DOI: 10.7270/Q2X351MD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein (Homo sapiens (Human)) | BDBM50032699 (CHEMBL3354677) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Inhibition of human recombinant matriptase using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis | J Med Chem 57: 10198-204 (2014) Article DOI: 10.1021/jm5015633 BindingDB Entry DOI: 10.7270/Q2DJ5H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50172383 (CHEMBL3809968) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting metho... | J Med Chem 59: 2962-72 (2016) Article DOI: 10.1021/acs.jmedchem.5b01549 BindingDB Entry DOI: 10.7270/Q23N258H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50172387 (CHEMBL3808761) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting metho... | J Med Chem 59: 2962-72 (2016) Article DOI: 10.1021/acs.jmedchem.5b01549 BindingDB Entry DOI: 10.7270/Q23N258H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50244579 (CHEMBL4094033) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]-[Nle75, Tyr77] Pyr1-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cell membranes after 1 hr by gamma-counti... | J Med Chem 61: 2266-2277 (2018) Article DOI: 10.1021/acs.jmedchem.7b01353 BindingDB Entry DOI: 10.7270/Q27M0BC2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein (Homo sapiens (Human)) | BDBM50032701 (CHEMBL3354679) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Inhibition of human recombinant matriptase using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis | J Med Chem 57: 10198-204 (2014) Article DOI: 10.1021/jm5015633 BindingDB Entry DOI: 10.7270/Q2DJ5H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566308 (CHEMBL4857085) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein (Homo sapiens (Human)) | BDBM50032697 (CHEMBL3354675) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Inhibition of human recombinant matriptase using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis | J Med Chem 57: 10198-204 (2014) Article DOI: 10.1021/jm5015633 BindingDB Entry DOI: 10.7270/Q2DJ5H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566302 (CHEMBL4878369) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566290 (CHEMBL4857851) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50565846 (CHEMBL4796315) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75, Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr by gamma ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01547 BindingDB Entry DOI: 10.7270/Q2V40ZZW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50172370 (CHEMBL3809767) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting metho... | J Med Chem 59: 2962-72 (2016) Article DOI: 10.1021/acs.jmedchem.5b01549 BindingDB Entry DOI: 10.7270/Q23N258H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50077994 (CHEMBL3417378) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr b... | J Med Chem 58: 2431-40 (2015) Article DOI: 10.1021/jm501916k BindingDB Entry DOI: 10.7270/Q21V5GNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50583259 (CHEMBL5094438) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I]-[Nle75,Tyr77][Pyr1]-Ape13 from YFP-tagged human APJ expressed in HEK293 cell membranes assessed as inhibition constant incubat... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01708 BindingDB Entry DOI: 10.7270/Q20R9T9K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50172369 (CHEMBL3810388) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting metho... | J Med Chem 59: 2962-72 (2016) Article DOI: 10.1021/acs.jmedchem.5b01549 BindingDB Entry DOI: 10.7270/Q23N258H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Suppressor of tumorigenicity 14 protein (Homo sapiens (Human)) | BDBM50032698 (CHEMBL3354676 | N-0130) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Inhibition of human recombinant matriptase using Boc-Gln-Ala-Arg-AMC as substrate by microplate reader analysis | J Med Chem 57: 10198-204 (2014) Article DOI: 10.1021/jm5015633 BindingDB Entry DOI: 10.7270/Q2DJ5H73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50244587 (CHEMBL4076652) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]-[Nle75, Tyr77] Pyr1-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cell membranes after 1 hr by gamma-counti... | J Med Chem 61: 2266-2277 (2018) Article DOI: 10.1021/acs.jmedchem.7b01353 BindingDB Entry DOI: 10.7270/Q27M0BC2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50066331 ((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universite£ de Sherbrooke Curated by ChEMBL | Assay Description Inhibition of thrombin | J Med Chem 54: 1961-2004 (2011) Article DOI: 10.1021/jm1012374 BindingDB Entry DOI: 10.7270/Q28C9XDV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50172368 (CHEMBL3809335) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting metho... | J Med Chem 59: 2962-72 (2016) Article DOI: 10.1021/acs.jmedchem.5b01549 BindingDB Entry DOI: 10.7270/Q23N258H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50078002 (CHEMBL3417389) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr b... | J Med Chem 58: 2431-40 (2015) Article DOI: 10.1021/jm501916k BindingDB Entry DOI: 10.7270/Q21V5GNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Appetite-regulating hormone (Homo sapiens (Human)) | BDBM50359261 (CHEMBL1923617) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc. Curated by ChEMBL | Assay Description Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay | J Med Chem 54: 8305-20 (2011) Article DOI: 10.1021/jm2007062 BindingDB Entry DOI: 10.7270/Q2930TK0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566280 (CHEMBL4859698) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Motilin receptor (Homo sapiens (Human)) | BDBM50002694 (MOTILIN) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc. Curated by ChEMBL | Assay Description Displacement of [125I]motilin from human MOTR | J Med Chem 49: 7190-7 (2006) Article DOI: 10.1021/jm0606600 BindingDB Entry DOI: 10.7270/Q2251JZH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50566305 (CHEMBL4849012) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of [125I] [NIe75,Tyr77]Pyr-apelin-13 from YFP-tagged human APJ receptor expressed in HEK293 cells incubated for 1 hr by gamma counting a... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01941 BindingDB Entry DOI: 10.7270/Q24F1VHS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50172388 (CHEMBL3809291) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting metho... | J Med Chem 59: 2962-72 (2016) Article DOI: 10.1021/acs.jmedchem.5b01549 BindingDB Entry DOI: 10.7270/Q23N258H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50172371 (CHEMBL3809818) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]-Apelin-13[Glp65, Nle75, Tyr77] from YFP epitope-tagged human APJ expressed in HEK-293 cells after 1 hr by gamma counting metho... | J Med Chem 59: 2962-72 (2016) Article DOI: 10.1021/acs.jmedchem.5b01549 BindingDB Entry DOI: 10.7270/Q23N258H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Apelin receptor (Homo sapiens (Human)) | BDBM50078006 (CHEMBL3417385) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Sherbrooke Curated by ChEMBL | Assay Description Displacement of [125I]apelin-13[Glp65,Nle75,Tyr77] from YFP epitope-tagged human APJ receptor expressed in HEK293 cell membranes incubated for 1 hr b... | J Med Chem 58: 2431-40 (2015) Article DOI: 10.1021/jm501916k BindingDB Entry DOI: 10.7270/Q21V5GNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine protease hepsin (Homo sapiens (Human)) | BDBM50032698 (CHEMBL3354676 | N-0130) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li... | Citation and Details Article DOI: 10.1038/s41586-022-04661-w BindingDB Entry DOI: 10.7270/Q2NP27M4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Appetite-regulating hormone (Homo sapiens (Human)) | BDBM50359239 (CHEMBL1923629) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.380 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tranzyme Pharma Inc. Curated by ChEMBL | Assay Description Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay | J Med Chem 54: 8305-20 (2011) Article DOI: 10.1021/jm2007062 BindingDB Entry DOI: 10.7270/Q2930TK0 | |||||||||||
More data for this Ligand-Target Pair |
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