Reaction Details |
| Report a problem with these data |
Target | Nicotinamide N-methyltransferase |
---|
Ligand | BDBM50566785 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2101683 (CHEMBL4810079) |
---|
IC50 | 52±n/a nM |
---|
Citation | Hayashi, K; Uehara, S; Yamamoto, S; Cary, DR; Nishikawa, J; Ueda, T; Ozasa, H; Mihara, K; Yoshimura, N; Kawai, T; Ono, T; Yamamoto, S; Fumoto, M; Mikamiyama, H Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell. ACS Med Chem Lett12:1093-1101 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Nicotinamide N-methyltransferase |
---|
Name: | Nicotinamide N-methyltransferase |
Synonyms: | NNMT | NNMT_HUMAN | Nicotinamide N-methyltransferase | Nicotinamide N-methyltransferase (NNMT) |
Type: | Protein |
Mol. Mass.: | 29571.16 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 264 |
Sequence: | MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
SYSSTMANNEGLFSLVARKLSRPL
|
|
|
BDBM50566785 |
---|
n/a |
---|
Name | BDBM50566785 |
Synonyms: | CHEMBL4868364 |
Type | Small organic molecule |
Emp. Form. | C56H73N11O10S |
Mol. Mass. | 1092.312 |
SMILES | CC(C)C[C@@H]1NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)CSC[C@H](NC(=O)[C@H](Cc2ccc(cc2)C(N)=O)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC1=O)C(N)=O |r| |
Structure |
|