Reaction Details |
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Target | Nicotinamide N-methyltransferase |
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Ligand | BDBM50566774 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2101684 (CHEMBL4810080) |
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IC50 | 214±n/a nM |
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Citation | Hayashi, K; Uehara, S; Yamamoto, S; Cary, DR; Nishikawa, J; Ueda, T; Ozasa, H; Mihara, K; Yoshimura, N; Kawai, T; Ono, T; Yamamoto, S; Fumoto, M; Mikamiyama, H Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell. ACS Med Chem Lett12:1093-1101 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nicotinamide N-methyltransferase |
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Name: | Nicotinamide N-methyltransferase |
Synonyms: | 2.1.1.1 | NNMT_MOUSE | Nicotinamide N-methyltransferase | Nnmt |
Type: | PROTEIN |
Mol. Mass.: | 29592.91 |
Organism: | Mus musculus |
Description: | ChEMBL_117911 |
Residue: | 264 |
Sequence: | MESGFTSKDTYLSHFNPRDYLEKYYSFGSRHCAENEILRHLLKNLFKIFCLGAVKGELLI
DIGSGPTIYQLLSACESFTEIIVSDYTDQNLWELQKWLKKEPGAFDWSPVVTYVCDLEGN
RMKGPEKEEKLRRAIKQVLKCDVTQSQPLGGVSLPPADCLLSTLCLDAACPDLPAYRTAL
RNLGSLLKPGGFLVMVDALKSSYYMIGEQKFSSLPLGWETVRDAVEEAGYTIEQFEVISQ
NYSSTTSNNEGLFSLVGRKPGRSE
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BDBM50566774 |
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n/a |
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Name | BDBM50566774 |
Synonyms: | CHEMBL4858283 |
Type | Small organic molecule |
Emp. Form. | C57H72F3N11O10S |
Mol. Mass. | 1160.309 |
SMILES | CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H](CN2C(=O)[C@H](Cc2ccccc2)NC(=O)CSC[C@H](NC(=O)[C@H](Cc2ccc(cc2)C(N)=O)NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC1=O)C(N)=O)C(F)(F)F |r| |
Structure |
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