| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nicotinamide N-methyltransferase |
|---|
| Ligand | BDBM50566787 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2101688 (CHEMBL4810084) |
|---|
| IC50 | 3490±n/a nM |
|---|
| Citation |  Hayashi, K; Uehara, S; Yamamoto, S; Cary, DR; Nishikawa, J; Ueda, T; Ozasa, H; Mihara, K; Yoshimura, N; Kawai, T; Ono, T; Yamamoto, S; Fumoto, M; Mikamiyama, H Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell. ACS Med Chem Lett12:1093-1101 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nicotinamide N-methyltransferase |
|---|
| Name: | Nicotinamide N-methyltransferase |
|---|
| Synonyms: | NNMT | NNMT_HUMAN | Nicotinamide N-methyltransferase | Nicotinamide N-methyltransferase (NNMT) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 29571.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 264 |
|---|
| Sequence: | MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
SYSSTMANNEGLFSLVARKLSRPL
|
|
|
|---|
| BDBM50566787 |
|---|
| n/a |
|---|
| Name | BDBM50566787 |
|---|
| Synonyms: | CHEMBL4846940 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C59H89N15O11S |
|---|
| Mol. Mass. | 1216.497 |
|---|
| SMILES | CC[C@H](C)[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)CSC[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC1=O)C(N)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
