Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM422160

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2102445 (CHEMBL4810841)

EC50

0.030000±n/a nM

Citation

Tora, G; Jiang, J; Bostwick, JS; Gargalovic, PS; Onorato, JM; Luk, CE; Generaux, C; Xu, C; Galella, MA; Wang, T; He, Y; Wexler, RR; Finlay, HJ Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists. Bioorg Med Chem Lett50:0 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM422160

n/a

Name

BDBM422160

Synonyms:

N-[4-(4-{[2-butyl-1- (2,6-dimethoxyphenyl)- 6-hydroxy-4-oxo-1,4- dihydropyrimidin-5- yl]sulfonyl}phenyl)pyri- din-2- yl]cyclopropane- carboxamide | US10508104, Example 51

Type

Small organic molecule

Emp. Form.

C31H32N4O7S

Mol. Mass.

604.673

SMILES

CCCCc1nc(=O)c(c(O)n1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-c1ccnc(NC(=O)C2CC2)c1 |(-10.77,.77,;-9.44,,;-8.11,.77,;-6.77,,;-5.44,.77,;-5.44,2.31,;-4.1,3.08,;-4.1,4.62,;-2.77,2.31,;-2.77,.77,;-1.44,,;-4.1,,;-4.1,-1.54,;-5.44,-2.31,;-6.77,-1.54,;-8.11,-2.31,;-5.44,-3.85,;-4.1,-4.62,;-2.77,-3.85,;-2.77,-2.31,;-1.44,-1.54,;-.1,-2.31,;-1.44,3.08,;-2.21,4.41,;-.67,4.41,;-.1,2.31,;-.1,.77,;1.23,,;2.56,.77,;2.56,2.31,;1.23,3.08,;3.9,,;3.9,-1.54,;5.23,-2.31,;6.57,-1.54,;6.57,,;7.9,.77,;7.9,2.31,;6.57,3.08,;9.23,3.08,;10.77,3.08,;10,4.41,;5.23,.77,)|

Structure