Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM50567162

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2102445 (CHEMBL4810841)

EC50

17±n/a nM

Citation

Tora, G; Jiang, J; Bostwick, JS; Gargalovic, PS; Onorato, JM; Luk, CE; Generaux, C; Xu, C; Galella, MA; Wang, T; He, Y; Wexler, RR; Finlay, HJ Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists. Bioorg Med Chem Lett50:0 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50567162

n/a

Name

BDBM50567162

Synonyms:

CHEMBL4866318

Type

Small organic molecule

Emp. Form.

C29H28FNO6S

Mol. Mass.

537.599

SMILES

CCCCc1[nH]c(=O)c(c(O)c1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-c1ccc(F)cc1 |(27.58,-36.46,;28.91,-37.23,;30.24,-36.46,;31.58,-37.23,;32.91,-36.47,;32.91,-34.92,;34.24,-34.15,;34.24,-32.61,;35.58,-34.91,;35.58,-36.46,;36.92,-37.23,;34.24,-37.24,;34.25,-38.77,;35.58,-39.54,;36.91,-38.76,;38.24,-39.53,;35.58,-41.07,;34.24,-41.85,;32.91,-41.08,;32.91,-39.54,;31.58,-38.77,;30.24,-39.54,;36.9,-34.14,;36.13,-32.8,;37.67,-32.79,;38.24,-34.9,;38.24,-36.44,;39.58,-37.2,;40.91,-36.43,;40.9,-34.88,;39.56,-34.12,;42.25,-37.19,;42.25,-38.73,;43.59,-39.5,;44.92,-38.72,;46.26,-39.48,;44.9,-37.17,;43.57,-36.42,)|

Structure