Ki Summary

Reaction Details

Report a problem with these data

Target

Apelin receptor

Ligand

BDBM50567167

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2102445 (CHEMBL4810841)

EC50

0.030000±n/a nM

Citation

Tora, G; Jiang, J; Bostwick, JS; Gargalovic, PS; Onorato, JM; Luk, CE; Generaux, C; Xu, C; Galella, MA; Wang, T; He, Y; Wexler, RR; Finlay, HJ Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists. Bioorg Med Chem Lett50:0 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50567167

n/a

Name

BDBM50567167

Synonyms:

CHEMBL4872192

Type

Small organic molecule

Emp. Form.

C28H27ClN2O7S

Mol. Mass.

571.041

SMILES

CCCCc1[nH]c(=O)c(c(O)c1-c1c(OC)cccc1OC)S(=O)(=O)c1ccc(cc1)-n1cc(Cl)ccc1=O |(2.32,-5.85,;3.65,-6.62,;4.99,-5.85,;6.33,-6.62,;7.66,-5.85,;7.66,-4.31,;8.99,-3.54,;8.98,-2,;10.32,-4.3,;10.33,-5.85,;11.66,-6.62,;8.99,-6.62,;8.99,-8.16,;10.32,-8.93,;11.66,-8.15,;12.99,-8.92,;10.33,-10.46,;8.99,-11.24,;7.66,-10.47,;7.66,-8.93,;6.32,-8.16,;4.99,-8.93,;11.65,-3.52,;10.87,-2.19,;12.42,-2.18,;12.99,-4.29,;12.99,-5.83,;14.33,-6.59,;15.66,-5.82,;15.65,-4.27,;14.31,-3.51,;16.99,-6.58,;17,-8.12,;18.33,-8.89,;18.34,-10.43,;19.67,-8.11,;19.65,-6.56,;18.32,-5.8,;18.3,-4.26,)|

Structure