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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium-dependent noradrenaline transporter | ||
| Ligand | BDBM50026952 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_142776 (CHEMBL750497) | ||
| IC50 | 22±n/a nM | ||
| Citation |  Axford, L; Boot, JR; Hotten, TM; Keenan, M; Martin, FM; Milutinovic, S; Moore, NA; O'Neill, MF; Pullar, IA; Tupper, DE; Van Belle, KR; Vivien, V Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression. Bioorg Med Chem Lett13:3277-80 (2003) [PubMed] | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium-dependent noradrenaline transporter | |||
| Name: | Sodium-dependent noradrenaline transporter | ||
| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 69337.72 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23975 | ||
| Residue: | 617 | ||
| Sequence: |
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| BDBM50026952 | |||
| n/a | |||
| Name | BDBM50026952 | ||
| Synonyms: | (cis) [3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmethyl]-dimethyl-amine(LR 5182) | CHEMBL322067 | LR 5182 | [(2R,3S)-3-(3,4-Dichloro-phenyl)-bicyclo[2.2.2]oct-2-ylmethyl]-dimethyl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H23Cl2N | ||
| Mol. Mass. | 312.277 | ||
| SMILES | CN(C)C[C@@H]1C2CCC(CC2)[C@@H]1c1ccc(Cl)c(Cl)c1 |wU:11.13,4.3,TLB:12:11:6.7:10.9,THB:3:4:6.7:10.9,(4.42,-5.07,;3.76,-3.67,;2.22,-3.53,;4.65,-2.41,;4,-1.01,;5.68,-.26,;5.79,1.35,;5.19,2.75,;5.16,1.21,;6.61,.69,;7.15,-.75,;3.76,.53,;2.43,1.3,;1.1,.53,;-.23,1.3,;-.23,2.84,;-1.58,3.63,;1.1,3.61,;1.1,5.15,;2.43,2.84,)| | ||
| Structure | 
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