| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
|---|
| Ligand | BDBM50132681 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_142778 (CHEMBL883548) |
|---|
| Ki | 68±n/a nM |
|---|
| Citation |  Axford, L; Boot, JR; Hotten, TM; Keenan, M; Martin, FM; Milutinovic, S; Moore, NA; O'Neill, MF; Pullar, IA; Tupper, DE; Van Belle, KR; Vivien, V Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression. Bioorg Med Chem Lett13:3277-80 (2003) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent noradrenaline transporter |
|---|
| Name: | Sodium-dependent noradrenaline transporter |
|---|
| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 69337.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23975 |
|---|
| Residue: | 617 |
|---|
| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
|
|
|
|---|
| BDBM50132681 |
|---|
| n/a |
|---|
| Name | BDBM50132681 |
|---|
| Synonyms: | CHEMBL323678 | [(2S,3S)-3-(6-Methoxy-naphthalen-2-yl)-bicyclo[2.2.1]hept-2-ylmethyl]-dimethyl-amine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H27NO |
|---|
| Mol. Mass. | 309.4452 |
|---|
| SMILES | COc1ccc2cc(ccc2c1)[C@H]1C2CCC(C2)[C@@H]1CN(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
