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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone deacetylase 2 | ||
| Ligand | BDBM50568209 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2104801 (CHEMBL4813304) | ||
| IC50 | 35±n/a nM | ||
| Citation |  Yu, W; Fells, J; Clausen, D; Liu, J; Klein, DJ; Christine Chung, C; Myers, RW; Wu, J; Wu, G; Howell, BJ; Barnard, RJO; Kozlowski, J Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation. Bioorg Med Chem Lett47:0 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone deacetylase 2 | |||
| Name: | Histone deacetylase 2 | ||
| Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 | ||
| Type: | Chromatin regulator; hydrolase; repressor | ||
| Mol. Mass.: | 55356.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q92769 | ||
| Residue: | 488 | ||
| Sequence: |
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| BDBM50568209 | |||
| n/a | |||
| Name | BDBM50568209 | ||
| Synonyms: | CHEMBL4853593 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C33H43N5O4 | ||
| Mol. Mass. | 573.7256 | ||
| SMILES | CCC(=O)CCCCC[C@@H]1NC(=O)[C@H]2CC22CCN(CC2)CCOCCn2ccc3cc(ccc3c2=O)-c2cnc1[nH]2 |r,wU:13.12,wD:9.8,(78.93,-40.88,;77.54,-40.24,;76.29,-41.13,;76.43,-42.66,;74.89,-40.49,;73.64,-41.38,;72.24,-40.74,;70.98,-41.63,;69.6,-40.99,;68.34,-41.88,;68.48,-43.41,;69.88,-44.06,;71.14,-43.16,;70.04,-45.57,;70.92,-46.83,;69.39,-46.96,;68.01,-46.18,;66.65,-46.96,;66.65,-48.55,;68.02,-49.34,;69.41,-48.55,;65.26,-49.35,;61.83,-47.66,;57.1,-47.99,;54.94,-45.64,;55.51,-42.82,;57.41,-41.01,;57.91,-39.53,;59.43,-39.23,;60.46,-40.39,;61.95,-40.11,;62.97,-41.26,;62.48,-42.72,;60.98,-43.03,;59.96,-41.87,;58.44,-42.17,;57.93,-43.7,;64.48,-40.96,;65.11,-39.56,;66.64,-39.74,;66.94,-41.24,;65.61,-41.99,)| | ||
| Structure | 
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