Ki Summary

Reaction Details

Report a problem with these data

Target

Receptor-type tyrosine-protein kinase FLT3

Ligand

BDBM50568700

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2106552 (CHEMBL4815227)

2.0±n/a nM

Citation

Long, Y; Yu, M; Ochnik, AM; Karanjia, JD; Basnet, SK; Kebede, AA; Kou, L; Wang, S Discovery of novel 4-azaaryl-N-phenylpyrimidin-2-amine derivatives as potent and selective FLT3 inhibitors for acute myeloid leukaemia with FLT3 mutations. Eur J Med Chem213:0 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Receptor-type tyrosine-protein kinase FLT3

Name:

Receptor-type tyrosine-protein kinase FLT3

Synonyms:

CD135 | CD_antigen: CD135 | FL cytokine receptor | FLK-2 | FLK2 | FLT-3 | FLT3 | FLT3_HUMAN | Fetal liver kinase-2 | Fms-like tyrosine kinase 3 | Fms-like tyrosine kinase 3 (Flt-3) | Fms-related tyrosine kinase 3 | STK-1 | STK1 | Stem cell tyrosine kinase 1

Type:

Enzyme

Mol. Mass.:

112888.62

Organism:

Homo sapiens (Human)

Description:

P36888

Residue:

993

Sequence:

MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP
EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL
QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD
ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE
CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM
STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE
IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA
ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE
GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD
NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD
LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS
ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE
HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL
NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS
NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK
LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS

BDBM50568700

n/a

Name

BDBM50568700

Synonyms:

CHEMBL4856641

Type

Small organic molecule

Emp. Form.

C26H25N7O

Mol. Mass.

451.523

SMILES

CC(=O)N1CCN(CC1)c1ccc(Nc2ncc(C#N)c(n2)-c2c(C)[nH]c3ccccc23)cc1 |(87.73,-8.05,;86.39,-7.28,;86.39,-5.74,;85.06,-8.05,;83.72,-7.29,;82.39,-8.06,;82.39,-9.6,;83.73,-10.37,;85.07,-9.6,;81.06,-10.38,;81.06,-11.93,;79.73,-12.69,;78.4,-11.93,;77.06,-12.7,;75.72,-11.93,;74.39,-12.7,;73.05,-11.93,;73.05,-10.39,;71.72,-9.62,;70.39,-8.86,;74.39,-9.61,;75.72,-10.38,;74.37,-8.07,;75.61,-7.17,;77.07,-7.64,;75.13,-5.7,;73.6,-5.71,;72.57,-4.57,;71.06,-4.89,;70.6,-6.36,;71.63,-7.49,;73.12,-7.18,;78.38,-10.39,;79.71,-9.61,)|

Structure