| Reaction Details |
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 | Report a problem with these data |
| Target | Mucolipin-3 |
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| Ligand | BDBM50569846 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2110663 (CHEMBL4819513) |
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| EC50 | 8500±n/a nM |
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| Citation |  Leser, C; Keller, M; Gerndt, S; Urban, N; Chen, CC; Schaefer, M; Grimm, C; Bracher, F Chemical and pharmacological characterization of the TRPML calcium channel blockers ML-SI1 and ML-SI3. Eur J Med Chem210:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mucolipin-3 |
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| Name: | Mucolipin-3 |
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| Synonyms: | MCLN3_HUMAN | MCOLN3 | MCOLN3 protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 64244.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8TDD5 |
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| Residue: | 553 |
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| Sequence: | MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKP
WKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQS
DVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPE
IETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYD
FTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSL
ILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKM
EIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAA
MIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRI
YLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLE
DDPPVSLFCCCKK
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| BDBM50569846 |
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| n/a |
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| Name | BDBM50569846 |
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| Synonyms: | CHEMBL4857820 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H33N3O3S |
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| Mol. Mass. | 443.602 |
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| SMILES | COc1ccccc1N1CCN(CC1)[C@H]1CCCC[C@@H]1NS(=O)(=O)c1ccc(C)cc1 |r| |
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| Structure | 
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