Reaction Details |
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Target | Mitogen-activated protein kinase 11 |
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Ligand | BDBM50135293 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_124653 |
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IC50 | 250±n/a nM |
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Citation | Liu, L; Stelmach, JE; Natarajan, SR; Chen, MH; Singh, SB; Schwartz, CD; Fitzgerald, CE; O'Keefe, SJ; Zaller, DM; Schmatz, DM; Doherty, JB SAR of 3,4-dihydropyrido[3,2-d]pyrimidone p38 inhibitors. Bioorg Med Chem Lett13:3979-82 (2003) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Mitogen-activated protein kinase 11 |
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Name: | Mitogen-activated protein kinase 11 |
Synonyms: | MAP kinase p38 | MAPK11 | MK11_HUMAN | Mitogen-activated protein kinase 11 | Mitogen-activated protein kinase p38 beta | PRKM11 | SAPK2 | SAPK2B | Stress-activated protein kinase 2 | p38 MAP kinase alpha/beta | p38-2 | p38-beta | p38b |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 41351.73 |
Organism: | Homo sapiens (Human) |
Description: | gi_20128774 |
Residue: | 364 |
Sequence: | MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQ
SLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQ
ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVG
TPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAA
EALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSL
EIEQ
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BDBM50135293 |
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n/a |
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Name | BDBM50135293 |
Synonyms: | 3-Chloro-4-[6-(4-fluoro-phenylsulfanyl)-2-oxo-3,4-dihydro-2H-pyrido[3,2-d]pyrimidin-1-yl]-5-methyl-benzoic acid methyl ester | CHEMBL129375 |
Type | Small organic molecule |
Emp. Form. | C22H17ClFN3O3S |
Mol. Mass. | 457.905 |
SMILES | COC(=O)c1cc(C)c(N2C(=O)NCc3nc(Sc4ccc(F)cc4)ccc23)c(Cl)c1 |
Structure |
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