| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 beta |
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| Ligand | BDBM50571742 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2115437 (CHEMBL4824378) |
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| IC50 | >10000±n/a nM |
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| Citation |  Liu, W; Liu, X; Tian, L; Gao, Y; Liu, W; Chen, H; Jiang, X; Xu, Z; Ding, H; Zhao, Q Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3?/DYRK1A dual inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem222:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 beta |
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| Name: | Glycogen synthase kinase-3 beta |
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| Synonyms: | GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B |
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| Type: | Enzyme |
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| Mol. Mass.: | 46756.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49841 |
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| Residue: | 420 |
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| Sequence: | MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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| BDBM50571742 |
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| n/a |
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| Name | BDBM50571742 |
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| Synonyms: | CHEMBL4868963 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13N3O2 |
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| Mol. Mass. | 279.2933 |
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| SMILES | O=Cc1ccc2c(c1)[nH]c1cnc(NC(=O)C3CC3)cc21 |
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| Structure | 
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