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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Potassium voltage-gated channel subfamily H member 2 | ||
| Ligand | BDBM50572484 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2117143 (CHEMBL4826209) | ||
| IC50 | 19800±n/a nM | ||
| Citation |  Kim, W; Kang, JA; Park, M; Jeong, PH; Kim, YJ; Cho, Y; Park, SG; Kim, YC Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents. J Med Chem64:5500-5518 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Potassium voltage-gated channel subfamily H member 2 | |||
| Name: | Potassium voltage-gated channel subfamily H member 2 | ||
| Synonyms: | 1,3-beta-glucan synthase component GLS2 | Cytochrome P450 3A4 | ERG | ERG1 | Eag-related protein 1 | Ether a-go-go related gene potassium channel (hERG) | Ether-a-go-go-related gene (HERG) | Ether-a-go-go-related gene potassium channel (hERG) | Ether-a-go-go-related gene potassium channel 1 | Ether-a-go-go-related gene potassium channel 1 (HERG) | Ether-a-go-go-related gene potassium channel 1 (hERG1) | Ether-a-go-go-related protein (hERG) | Ether-a-go-go-related protein 1 | Ether-a-go-go-related protein 1 (HERG) | H-ERG | HERG | KCNH2 | KCNH2_HUMAN | Potassium voltage-gated channel subfamily H member 2 (hERG) | Transcriptional regulator ERG | Voltage-gated potassium channel subunit Kv11.1 | eag homolog | hERG Potassium Channel 1 | putative potassium channel subunit | ||
| Type: | Multi-pass membrane protein | ||
| Mol. Mass.: | 126672.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q12809 | ||
| Residue: | 1159 | ||
| Sequence: |
| ||
| BDBM50572484 | |||
| n/a | |||
| Name | BDBM50572484 | ||
| Synonyms: | CHEMBL4850078 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H21ClFN5O2S | ||
| Mol. Mass. | 413.897 | ||
| SMILES | CS(=O)(=O)c1nc(NC2CCC(N)CC2)cc(Nc2ccc(F)c(Cl)c2)n1 |(20.3,-54.65,;21.63,-55.42,;22.39,-56.75,;20.86,-56.74,;22.97,-54.65,;24.3,-55.42,;25.64,-54.65,;26.98,-55.42,;26.98,-56.96,;25.65,-57.73,;25.64,-59.26,;26.98,-60.04,;26.97,-61.58,;28.31,-59.27,;28.32,-57.72,;25.64,-53.1,;24.3,-52.34,;24.3,-50.8,;25.63,-50.02,;26.96,-50.79,;28.29,-50.02,;28.29,-48.48,;29.62,-47.7,;26.94,-47.71,;26.93,-46.17,;25.62,-48.49,;22.97,-53.11,)| | ||
| Structure | 
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