| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calcium/calmodulin-dependent protein kinase kinase 2 |
|---|
| Ligand | BDBM50271789 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2118505 (CHEMBL4827571) |
|---|
| IC50 | 26±n/a nM |
|---|
| Citation |  Eduful, BJ; O'Byrne, SN; Temme, L; Asquith, CRM; Liang, Y; Picado, A; Pilotte, JR; Hossain, MA; Wells, CI; Zuercher, WJ; Catta-Preta, CMC; Zonzini Ramos, P; Santiago, AS; Couņago, RM; Langendorf, CG; Nay, K; Oakhill, JS; Pulliam, TL; Lin, C; Awad, D; Willson, TM; Frigo, DE; Scott, JW; Drewry, DH Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes. J Med Chem64:10849-10877 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calcium/calmodulin-dependent protein kinase kinase 2 |
|---|
| Name: | Calcium/calmodulin-dependent protein kinase kinase 2 |
|---|
| Synonyms: | CAMKK2 | CAMKKB | Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKKB) | Calcium/calmodulin-dependent protein kinase kinase beta | KIAA0787 | KKCC2_HUMAN |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 64746.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_27437015 |
|---|
| Residue: | 588 |
|---|
| Sequence: | MSSCVSSQPSSNRAAPQDELGGRGSSSSESQKPCEALRGLSSLSIHLGMESFIVVTECEP
GCAVDLGLARDRPLEADGQEVPLDTSGSQARPHLSGRKLSLQERSQGGLAAGGSLDMNGR
CICPSLPYSPVSSPQSSPRLPRRPTVESHHVSITGMQDCVQLNQYTLKDEIGKGSYGVVK
LAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAIL
KKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGI
EYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLS
ETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLK
DLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPS
LATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTRECESLSELKEARQRRQP
PGHRPAPRGGGGSALVRGSPCVESCWAPAPGSPARMHPLRPEEAMEPE
|
|
|
|---|
| BDBM50271789 |
|---|
| n/a |
|---|
| Name | BDBM50271789 |
|---|
| Synonyms: | CHEMBL4125686 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H18N2O2 |
|---|
| Mol. Mass. | 306.3584 |
|---|
| SMILES | OC(=O)c1ccc(cc1C1CCCC1)-c1c[nH]c2ncccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
