| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 6 |
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| Ligand | BDBM50574180 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2121954 (CHEMBL4831101) |
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| Ki | 6.5±n/a nM |
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| Citation |  Wichur, T; Gody?, J; Góral, I; Latacz, G; Bucki, A; Siwek, A; G?uch-Lutwin, M; Mordyl, B; ?niecikowska, J; Walczak, M; Knez, D; Juki?, M; Sa?at, K; Gobec, S; Ko?aczkowski, M; Malawska, B; Brazzolotto, X; Wi?ckowska, A Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT Eur J Med Chem225:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 6 |
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| Name: | 5-hydroxytryptamine receptor 6 |
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| Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46968.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50406 |
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| Residue: | 440 |
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| Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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| BDBM50574180 |
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| n/a |
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| Name | BDBM50574180 |
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| Synonyms: | CHEMBL4867606 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24N2O5S |
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| Mol. Mass. | 464.533 |
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| SMILES | CC(=O)Oc1cccc(CNCCOc2cccc3n(ccc23)S(=O)(=O)c2ccccc2)c1 |
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| Structure | 
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