Reaction Details |
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Target | Procathepsin L |
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Ligand | BDBM50574821 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2123443 (CHEMBL4832676) |
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Ki | 266±n/a nM |
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Citation | Jung, S; Fuchs, N; Johe, P; Wagner, A; Diehl, E; Yuliani, T; Zimmer, C; Barthels, F; Zimmermann, RA; Klein, P; Waigel, W; Meyr, J; Opatz, T; Tenzer, S; Distler, U; Räder, HJ; Kersten, C; Engels, B; Hellmich, UA; Klein, J; Schirmeister, T Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies. J Med Chem64:12322-12358 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Procathepsin L |
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Name: | Procathepsin L |
Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
Type: | Enzyme |
Mol. Mass.: | 37557.19 |
Organism: | Homo sapiens (Human) |
Description: | Purchased from Calbiochem (San Diego, CA). |
Residue: | 333 |
Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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BDBM50574821 |
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n/a |
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Name | BDBM50574821 |
Synonyms: | CHEMBL4864383 |
Type | Small organic molecule |
Emp. Form. | C33H32FN3O5S |
Mol. Mass. | 601.688 |
SMILES | Cc1cccc(C[C@H](NC(=O)c2ccncc2)C(=O)N[C@@H](CCc2ccccc2)\C=C(/F)S(=O)(=O)Oc2ccccc2)c1 |r| |
Structure |
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