| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear factor erythroid 2-related factor 2 |
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| Ligand | BDBM50575939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2126179 (CHEMBL4835524) |
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| Ki | 1500±n/a nM |
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| Citation |  Pallesen, JS; Narayanan, D; Tran, KT; Solbak, SMØ; Marseglia, G; Sørensen, LME; Høj, LJ; Munafò, F; Carmona, RMC; Garcia, AD; Desu, HL; Brambilla, R; Johansen, TN; Popowicz, GM; Sattler, M; Gajhede, M; Bach, A Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds. J Med Chem64:4623-4661 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear factor erythroid 2-related factor 2 |
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| Name: | Nuclear factor erythroid 2-related factor 2 |
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| Synonyms: | HEBP1 | Kelch-like ECH-associated protein 1 | NF-E2-related factor 2 | NF2L2_HUMAN | NFE2-related factor 2 | NFE2L2 | NRF2 | Nuclear factor erythroid 2-related factor 2 | Nuclear factor, erythroid derived 2, like 2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67786.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107924 |
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| Residue: | 605 |
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| Sequence: | MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE
QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM
QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG
NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP
SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS
VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA
QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD
FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL
KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP
DVKKN
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| BDBM50575939 |
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| n/a |
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| Name | BDBM50575939 |
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| Synonyms: | CHEMBL4872869 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H27N3O4S |
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| Mol. Mass. | 501.597 |
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| SMILES | Cc1cc(C)c(c(C)c1)S(=O)(=O)Nc1cccc(c1)-n1ncc(C(O)=O)c1[C@H]1C[C@@H]1c1ccccc1 |r| |
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| Structure | 
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