Reaction Details |
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Target | Eukaryotic initiation factor 4A-I |
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Ligand | BDBM50576670 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2127676 (CHEMBL4837021) |
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IC50 | 5.0±n/a nM |
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Citation | Nilewski, C; Michels, TD; Packard, GK; Xiang, AX; Sprengeler, PA; Eam, B; Fish, S; Thompson, PA; Wegerski, CJ; Nevarez, A; Clarine, J; Sperry, S; Ernst, JT; Reich, SH 1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties. Bioorg Med Chem Lett47:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Eukaryotic initiation factor 4A-I |
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Name: | Eukaryotic initiation factor 4A-I |
Synonyms: | ATP-dependent RNA helicase eIF4A-1 | DDX2A | EIF4A | EIF4A1 | IF4A1_HUMAN | eIF-4A-I | eIF4A-I |
Type: | PROTEIN |
Mol. Mass.: | 46146.87 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_864983 |
Residue: | 406 |
Sequence: | MSASQDSRSRDNGPDGMEPEGVIESNWNEIVDSFDDMNLSESLLRGIYAYGFEKPSAIQQ
RAILPCIKGYDVIAQAQSGTGKTATFAISILQQIELDLKATQALVLAPTRELAQQIQKVV
MALGDYMGASCHACIGGTNVRAEVQKLQMEAPHIIVGTPGRVFDMLNRRYLSPKYIKMFV
LDEADEMLSRGFKDQIYDIFQKLNSNTQVVLLSATMPSDVLEVTKKFMRDPIRILVKKEE
LTLEGIRQFYINVEREEWKLDTLCDLYETLTITQAVIFINTRRKVDWLTEKMHARDFTVS
AMHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRI
GRGGRFGRKGVAINMVTEEDKRTLRDIETFYNTSIEEMPLNVADLI
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BDBM50576670 |
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n/a |
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Name | BDBM50576670 |
Synonyms: | CHEMBL4864162 |
Type | Small organic molecule |
Emp. Form. | C24H23BrN2O3 |
Mol. Mass. | 467.355 |
SMILES | COc1cncc2O[C@]3([C@@H](C[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 |r| |
Structure |
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