| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 8 |
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| Ligand | BDBM50578342 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2132756 (CHEMBL4842271) |
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| IC50 | 1450±n/a nM |
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| Citation |  Nagy, MA; Hilgraf, R; Mortensen, DS; Elsner, J; Norris, S; Tikhe, J; Yoon, W; Paisner, D; Delgado, M; Erdman, P; Haelewyn, J; Khambatta, G; Xu, L; Romanow, WJ; Condroski, K; Bahmanyar, S; McCarrick, M; Benish, B; Blease, K; LeBrun, L; Moghaddam, MF; Apuy, J; Canan, SS; Bennett, BL; Satoh, Y Discovery of the c-Jun N-Terminal Kinase Inhibitor J Med Chem64:18193-18208 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 8 |
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| Name: | Mitogen-activated protein kinase 8 |
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| Synonyms: | Jnk1 | MAP kinase 8 | MAPK 8 | MK08_MOUSE | Mapk8 | Prkm8 | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44234.80 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_120521 |
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| Residue: | 384 |
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| Sequence: | MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLAQVQQ
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| BDBM50578342 |
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| n/a |
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| Name | BDBM50578342 |
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| Synonyms: | CHEMBL4861369 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H19N5O3 |
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| Mol. Mass. | 365.3859 |
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| SMILES | COc1ccc(Nc2ncc(C(N)=O)c(Nc3ccccc3)n2)cc1OC |
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| Structure | 
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