| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 4 |
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| Ligand | BDBM50009366 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2133973 (CHEMBL4843583) |
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| IC50 | >1000±n/a nM |
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| Citation |  ?imková, A; Ormsby, T; Sidej, N; Slav?tínská, LP; Brynda, J; Beranová, J; ?ácha, P; Majer, P; Konvalinka, J Structure-activity relationship and biochemical evaluation of novel fibroblast activation protein and prolyl endopeptidase inhibitors with ?-ketoamide warheads. Eur J Med Chem224:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 4 |
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| Name: | Dipeptidyl peptidase 4 |
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| Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 |
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| Type: | Enzyme |
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| Mol. Mass.: | 88271.01 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27487 |
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| Residue: | 766 |
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| Sequence: | MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSL
RWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL
PSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYL
CDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPS
EPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISN
EYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLY
TLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKY
PLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWE
YYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQIS
KALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
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| BDBM50009366 |
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| n/a |
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| Name | BDBM50009366 |
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| Synonyms: | CHEMBL3233842 | US11504364, Compound Ref.-Comp. | US9346814, Cmpd No 1, Example 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14F2N4O2 |
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| Mol. Mass. | 344.3155 |
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| SMILES | FC1(F)C[C@@H](C#N)N(C1)C(=O)CNC(=O)c1ccnc2ccccc12 |r| |
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| Structure | 
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