Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50579327 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2134899 (CHEMBL4844509) |
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Ki | 2.0±n/a nM |
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Citation | Wichur, T; Pasieka, A; Gody?, J; Panek, D; Góral, I; Latacz, G; Honkisz-Orzechowska, E; Bucki, A; Siwek, A; G?uch-Lutwin, M; Knez, D; Brazzolotto, X; Gobec, S; Ko?aczkowski, M; Sabate, R; Malawska, B; Wi?ckowska, A Discovery of 1-(phenylsulfonyl)-1H-indole-based multifunctional ligands targeting cholinesterases and 5-HT Eur J Med Chem225:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50579327 |
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n/a |
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Name | BDBM50579327 |
Synonyms: | CHEMBL4847532 |
Type | Small organic molecule |
Emp. Form. | C25H26ClN3O3S |
Mol. Mass. | 484.01 |
SMILES | Clc1cccc(CNCCNCCOc2cccc3n(ccc23)S(=O)(=O)c2ccccc2)c1 |
Structure |
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