| Reaction Details |
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 | Report a problem with these data |
| Target | Mast/stem cell growth factor receptor Kit |
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| Ligand | BDBM445983 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2135286 (CHEMBL4844896) |
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| IC50 | 5800±n/a nM |
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| Citation |  Kwon, SH; Kim, S; Park, AY; Lee, S; Gadhe, CG; Seo, BA; Park, JS; Jo, S; Oh, Y; Kweon, SH; Ma, SX; Kim, WR; Kim, M; Kim, H; Kim, JE; Lee, S; Lee, J; Ko, HS A Novel, Selective c-Abl Inhibitor, Compound 5, Prevents Neurodegeneration in Parkinson's Disease. J Med Chem64:15091-15110 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mast/stem cell growth factor receptor Kit |
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| Name: | Mast/stem cell growth factor receptor Kit |
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| Synonyms: | CD117 antigen | CD_antigen=CD117 | KIT | KIT_HUMAN | Mast/stem cell growth factor receptor Kit (cKIT) | Proto-oncogene c-Kit | Proto-oncogene tyrosine-protein kinase Kit | SCFR | Stem cell growth factor receptor | Tyrosine Kinase c-Kit | Tyrosine-protein kinase Kit | Tyrosine-protein kinase Kit (c-Kit) | c-kit | p-145 c-kit | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
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| Type: | Protein |
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| Mol. Mass.: | 109869.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10721 |
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| Residue: | 976 |
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| Sequence: | MRGARGAWDFLCVLLLLLRVQTGSSQPSVSPGEPSPPSIHPGKSDLIVRVGDEIRLLCTD
PGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLV
DRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYH
RLCLHCSVDQEGKSVLSEKFILKVRPAFKAVPVVSVSKASYLLREGEEFTVTCTIKDVSS
SVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLTISSARVNDSGVFMCYANNTFGSAN
VTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQWIYMNRTFTDKWE
DYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTKPEILTYDR
LVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKLVVQSSIDS
SAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHPHTLFTPLLIGFVIVAGMMCIIV
MILTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAF
GKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGAC
TIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNE
YMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGM
AFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPES
IFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMLSPEHAPAEMY
DIMKTCWDADPLKRPTFKQIVQLIEKQISESTNHIYSNLANCSPNRQKPVVDHSVRINSV
GSTASSSQPLLVHDDV
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| BDBM445983 |
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| n/a |
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| Name | BDBM445983 |
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| Synonyms: | US10669246, Example 36 | US10968188, Example 36 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13F2N3OS |
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| Mol. Mass. | 345.366 |
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| SMILES | Cc1ccncc1-c1ccc2nc(NC(=O)C3CC3(F)F)sc2c1 |
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| Structure | 
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