| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50148089 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_153394 (CHEMBL763847) |
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| EC50 | 100±n/a nM |
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| Citation |  Koyama, H; Miller, DJ; Boueres, JK; Desai, RC; Jones, AB; Berger, JP; MacNaul, KL; Kelly, LJ; Doebber, TW; Wu, MS; Zhou, G; Wang, PR; Ippolito, MC; Chao, YS; Agrawal, AK; Franklin, R; Heck, JV; Wright, SD; Moller, DE; Sahoo, SP (2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents. J Med Chem47:3255-63 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50148089 |
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| n/a |
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| Name | BDBM50148089 |
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| Synonyms: | 2-Methyl-7-[3-(4-phenoxy-2-propyl-phenoxy)-propoxy]-chroman-2-carboxylic acid | CHEMBL324449 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H32O6 |
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| Mol. Mass. | 476.5608 |
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| SMILES | CCCc1cc(Oc2ccccc2)ccc1OCCCOc1ccc2CCC(C)(Oc2c1)C(O)=O |
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| Structure | 
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