| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor delta |
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| Ligand | BDBM50148098 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_154045 (CHEMBL760850) |
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| IC50 | >15000±n/a nM |
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| Citation |  Koyama, H; Miller, DJ; Boueres, JK; Desai, RC; Jones, AB; Berger, JP; MacNaul, KL; Kelly, LJ; Doebber, TW; Wu, MS; Zhou, G; Wang, PR; Ippolito, MC; Chao, YS; Agrawal, AK; Franklin, R; Heck, JV; Wright, SD; Moller, DE; Sahoo, SP (2R)-2-ethylchromane-2-carboxylic acids: discovery of novel PPARalpha/gamma dual agonists as antihyperglycemic and hypolipidemic agents. J Med Chem47:3255-63 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor delta |
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| Name: | Peroxisome proliferator-activated receptor delta |
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| Synonyms: | NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta |
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| Type: | Enzyme |
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| Mol. Mass.: | 49910.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q03181 |
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| Residue: | 441 |
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| Sequence: | MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQM
GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKK
NRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSK
HIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKE
ISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNK
DGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGD
RPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRI
KKTETETSLHPLLQEIYKDMY
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| BDBM50148098 |
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| n/a |
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| Name | BDBM50148098 |
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| Synonyms: | (S)-7-[3-(2-Chloro-4-phenoxy-phenoxy)-propoxy]-2-methyl-chroman-2-carboxylic acid | CHEMBL112790 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25ClO6 |
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| Mol. Mass. | 468.926 |
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| SMILES | C[C@]1(CCc2ccc(OCCCOc3ccc(Oc4ccccc4)cc3Cl)cc2O1)C(O)=O |
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| Structure | 
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