| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cell division protein FtsZ |
|---|
| Ligand | BDBM50079356 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2149630 (CHEMBL5034092) |
|---|
| Kd | <100±n/a nM |
|---|
| Citation |  Huecas, S; Araújo-Bazán, L; Ruiz, FM; Ruiz-Ávila, LB; Martínez, RF; Escobar-Peńa, A; Artola, M; Vázquez-Villa, H; Martín-Fontecha, M; Fernández-Tornero, C; López-Rodríguez, ML; Andreu, JM Targeting the FtsZ Allosteric Binding Site with a Novel Fluorescence Polarization Screen, Cytological and Structural Approaches for Antibacterial Discovery. J Med Chem64:5730-5745 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cell division protein FtsZ |
|---|
| Name: | Cell division protein FtsZ |
|---|
| Synonyms: | n/a |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 40375.29 |
|---|
| Organism: | Bacillus subtilis |
|---|
| Description: | ChEMBL_107642 |
|---|
| Residue: | 382 |
|---|
| Sequence: | MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVNTDAQALNLSKAEVKMQ
IGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVTAGMGGGTGTGAAPVIAQI
AKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDTLIVIPNDRILEIVDKNTPML
EAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIMSNKGSALMGIGIATGENRAAEA
AKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQEAADIVASASDQDVNMIFGSVINE
NLKDEIVVTVIATGFIEQEKDVTKSQRPSLNQSIKTHNQSVPKREPKREEPQQQNTVSRH
TSQPADDTLDIPTFLRNRNKRG
|
|
|
|---|
| BDBM50079356 |
|---|
| n/a |
|---|
| Name | BDBM50079356 |
|---|
| Synonyms: | CHEMBL511201 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H8ClF2N3O2S |
|---|
| Mol. Mass. | 355.747 |
|---|
| SMILES | NC(=O)c1c(F)ccc(OCc2nc3cc(Cl)cnc3s2)c1F |
|---|
| Structure | 
|
|---|
Search and Browse
