| Reaction Details |
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 | Report a problem with these data |
| Target | Cruzipain |
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| Ligand | BDBM50581372 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2150847 (CHEMBL5035309) |
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| Ki | 0.500000±n/a nM |
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| Citation |  Li, L; Chenna, BC; Yang, KS; Cole, TR; Goodall, ZT; Giardini, M; Moghadamchargari, Z; Hernandez, EA; Gomez, J; Calvet, CM; Bernatchez, JA; Mellott, DM; Zhu, J; Rademacher, A; Thomas, D; Blankenship, LR; Drelich, A; Laganowsky, A; Tseng, CK; Liu, WR; Wand, AJ; Cruz-Reyes, J; Siqueira-Neto, JL; Meek, TD Self-Masked Aldehyde Inhibitors: A Novel Strategy for Inhibiting Cysteine Proteases. J Med Chem64:11267-11287 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cruzipain |
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| Name: | Cruzipain |
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| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
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| Type: | Protein |
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| Mol. Mass.: | 49831.41 |
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| Organism: | Trypanosoma cruzi |
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| Description: | P25779 |
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| Residue: | 467 |
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| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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| BDBM50581372 |
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| n/a |
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| Name | BDBM50581372 |
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| Synonyms: | CHEMBL5079418 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H32N4O3 |
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| Mol. Mass. | 436.5466 |
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| SMILES | CN1CCN(CC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCc1ccccc1)C=O |r| |
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| Structure | 
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