| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50582538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2154908 (CHEMBL5039568) |
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| IC50 | 16000±n/a nM |
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| Citation |  Tilekar, K; Hess, JD; Upadhyay, N; Bianco, AL; Schweipert, M; Laghezza, A; Loiodice, F; Meyer-Almes, FJ; Aguilera, RJ; Lavecchia, A; C S, R Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPAR? and HDACs: Design, Synthesis, and Investigations of their J Med Chem64:6949-6971 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50582538 |
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| n/a |
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| Name | BDBM50582538 |
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| Synonyms: | CHEMBL5091419 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H15BrN2O4S |
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| Mol. Mass. | 483.335 |
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| SMILES | Brc1ccc(NC(=O)COc2ccc3cc(\C=C4\SC(=O)NC4=O)ccc3c2)cc1 |
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| Structure | 
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