| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone deacetylase 8 |
|---|
| Ligand | BDBM50582547 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2154908 (CHEMBL5039568) |
|---|
| IC50 | 5800±n/a nM |
|---|
| Citation |  Tilekar, K; Hess, JD; Upadhyay, N; Bianco, AL; Schweipert, M; Laghezza, A; Loiodice, F; Meyer-Almes, FJ; Aguilera, RJ; Lavecchia, A; C S, R Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPAR? and HDACs: Design, Synthesis, and Investigations of their J Med Chem64:6949-6971 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone deacetylase 8 |
|---|
| Name: | Histone deacetylase 8 |
|---|
| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41749.60 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9BY41 |
|---|
| Residue: | 377 |
|---|
| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
|
|
|
|---|
| BDBM50582547 |
|---|
| n/a |
|---|
| Name | BDBM50582547 |
|---|
| Synonyms: | CHEMBL5082258 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H17N3O4S2 |
|---|
| Mol. Mass. | 475.539 |
|---|
| SMILES | Cc1cccc2sc(NC(=O)COc3ccc4cc(\C=C5\SC(=O)NC5=O)ccc4c3)nc12 |
|---|
| Structure | 
|
|---|
Search and Browse
