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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50152161 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_303525 (CHEMBL839639) | ||
| Ki | 20±n/a nM | ||
| Citation |  Chen, C; Wilcoxen, KM; Huang, CQ; Xie, YF; McCarthy, JR; Webb, TR; Zhu, YF; Saunders, J; Liu, XJ; Chen, TK; Bozigian, H; Grigoriadis, DE Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists. J Med Chem47:4787-98 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50152161 | |||
| n/a | |||
| Name | BDBM50152161 | ||
| Synonyms: | CHEMBL364828 | [3-(6-Dimethylamino-2,4-dimethyl-pyridin-3-yl)-5-methyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H32N6 | ||
| Mol. Mass. | 380.5297 | ||
| SMILES | CCCN(CCC)c1cc(C)nc2c(cnn12)-c1c(C)cc(nc1C)N(C)C |(3.92,5.72,;4.4,4.25,;3.38,3.12,;3.87,1.65,;5.38,1.35,;6.4,2.49,;7.89,2.19,;2.84,.51,;3.33,-.94,;2.31,-2.1,;2.79,-3.55,;.82,-1.77,;.33,-.33,;-1.07,.3,;-.93,1.84,;.59,2.16,;1.35,.82,;-2.39,-.47,;-3.73,.29,;-3.75,1.84,;-5.07,-.47,;-5.07,-2.03,;-3.73,-2.79,;-2.39,-2.03,;-1.07,-2.79,;-6.4,-2.79,;-7.75,-2.03,;-6.4,-4.33,)| | ||
| Structure | 
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