Compile Data Set for Download or QSAR

Found 449 hits with Last Name = 'bozigian' and Initial = 'h'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50162026 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C)N(C)Cc2ccccn2)c1=O |wU:26.28,(2.12,4.82,;3.44,4.05,;3.44,2.51,;4.79,1.73,;4.77,.19,;3.44,-.57,;2.12,.2,;2.12,1.74,;.78,2.51,;.78,-.57,;.78,-2.11,;2.12,-2.87,;-.55,-2.87,;-.55,-4.39,;.78,-5.18,;2.12,-4.39,;.78,-3.64,;3.44,-5.16,;3.44,-6.72,;2.12,-7.47,;.78,-6.72,;-.55,-7.47,;-1.87,-2.11,;-3.21,-2.87,;-1.87,-.57,;-3.21,.2,;-3.21,1.74,;-1.88,2.51,;-4.57,2.51,;-5.9,1.74,;-4.57,4.05,;-3.24,4.82,;-1.91,4.04,;-.56,4.82,;-.56,6.35,;-1.93,7.12,;-3.24,6.35,;-.55,.21,;-.55,1.77,)| Show InChI InChI=1S/C29H29F3N4O3/c1-18(34(3)16-20-9-5-6-14-33-20)15-36-28(37)26(21-10-7-13-25(39-4)27(21)32)19(2)35(29(36)38)17-22-23(30)11-8-12-24(22)31/h5-14,18H,15-17H2,1-4H3/t18-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50261243 ((R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-am...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2C(F)(F)F)c(=O)n(C[C@H](N)c2ccccc2)c1=O |r,wD:29.31,(2.33,6.39,;1,5.62,;1.01,4.08,;2.35,3.31,;2.35,1.77,;1.02,.99,;-.31,1.77,;-.32,3.3,;-1.66,4.06,;-1.64,1,;-1.64,-.54,;-.31,-1.32,;-2.97,-1.31,;-2.97,-2.85,;-1.64,-3.62,;-.32,-2.85,;-1.66,-2.08,;1.02,-3.61,;1.02,-5.16,;-.31,-5.93,;-1.65,-5.16,;-2.98,-5.92,;-4.32,-6.68,;-2.22,-7.26,;-3.74,-4.59,;-4.3,-.54,;-5.63,-1.32,;-4.3,1,;-5.64,1.76,;-6.97,.99,;-6.96,-.55,;-8.3,1.75,;-8.3,3.29,;-9.64,4.06,;-10.97,3.28,;-10.96,1.74,;-9.62,.98,;-2.97,1.77,;-2.97,3.31,)| Show InChI InChI=1S/C28H24F5N3O3/c1-16-24(18-10-6-13-23(39-2)25(18)30)26(37)36(15-22(34)17-8-4-3-5-9-17)27(38)35(16)14-19-20(28(31,32)33)11-7-12-21(19)29/h3-13,22H,14-15,34H2,1-2H3/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation counting				J Med Chem 51: 7478-85 (2009) Article DOI: 10.1021/jm8006454 BindingDB Entry DOI: 10.7270/Q2S46RT8
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50162007 ((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)c2ccccc2)c1=O |r,wD:26.28,(6.65,3.5,;5.31,2.74,;3.98,3.51,;3.98,5.05,;2.64,5.83,;1.31,5.06,;1.31,3.52,;2.64,2.75,;2.64,1.21,;-.02,2.76,;-.02,1.22,;1.3,.46,;-1.35,.46,;-1.35,-1.08,;-.01,-1.85,;1.31,-1.08,;2.64,-.3,;2.64,-1.85,;2.65,-3.39,;1.31,-4.16,;-.02,-3.39,;-1.36,-4.16,;-2.68,1.22,;-4.01,.45,;-2.68,2.76,;-4.01,3.53,;-5.34,2.75,;-5.34,1.21,;-6.68,3.52,;-6.68,5.06,;-8.02,5.83,;-9.36,5.04,;-9.35,3.51,;-8.01,2.75,;-1.35,3.54,;-1.35,5.08,)| Show InChI InChI=1S/C27H24F3N3O3/c1-16-24(18-10-6-13-23(36-2)25(18)30)26(34)33(15-22(31)17-8-4-3-5-9-17)27(35)32(16)14-19-20(28)11-7-12-21(19)29/h3-13,22H,14-15,31H2,1-2H3/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation counting				J Med Chem 51: 7478-85 (2009) Article DOI: 10.1021/jm8006454 BindingDB Entry DOI: 10.7270/Q2S46RT8
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50162007 ((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)c2ccccc2)c1=O |r,wD:26.28,(6.65,3.5,;5.31,2.74,;3.98,3.51,;3.98,5.05,;2.64,5.83,;1.31,5.06,;1.31,3.52,;2.64,2.75,;2.64,1.21,;-.02,2.76,;-.02,1.22,;1.3,.46,;-1.35,.46,;-1.35,-1.08,;-.01,-1.85,;1.31,-1.08,;2.64,-.3,;2.64,-1.85,;2.65,-3.39,;1.31,-4.16,;-.02,-3.39,;-1.36,-4.16,;-2.68,1.22,;-4.01,.45,;-2.68,2.76,;-4.01,3.53,;-5.34,2.75,;-5.34,1.21,;-6.68,3.52,;-6.68,5.06,;-8.02,5.83,;-9.36,5.04,;-9.35,3.51,;-8.01,2.75,;-1.35,3.54,;-1.35,5.08,)| Show InChI InChI=1S/C27H24F3N3O3/c1-16-24(18-10-6-13-23(36-2)25(18)30)26(34)33(15-22(31)17-8-4-3-5-9-17)27(35)32(16)14-19-20(28)11-7-12-21(19)29/h3-13,22H,14-15,31H2,1-2H3/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.560	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50221119 (CHEMBL236521 | N-((S)-1-(2-(4-((R)-3-(2,4-dichloro...) Show SMILES CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1Cl)N1CCCC1=O Show InChI InChI=1S/C34H47Cl2N5O3/c1-23(2)19-29(37-32(42)12-14-38(4)5)27-20-24(3)8-11-30(27)39-15-17-40(18-16-39)34(44)31(41-13-6-7-33(41)43)21-25-9-10-26(35)22-28(25)36/h8-11,20,22-23,29,31H,6-7,12-19,21H2,1-5H3,(H,37,42)/t29-,31+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cells				J Med Chem 50: 6356-66 (2007) Article DOI: 10.1021/jm701137s BindingDB Entry DOI: 10.7270/Q2P84BM9
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50224184 (1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...) Show SMILES CC(C)[C@H](NC(=O)CCN(C)C)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1C |r| Show InChI InChI=1S/C31H45ClN4O2/c1-21(2)30(33-29(37)12-13-34(6)7)27-18-22(3)8-11-28(27)35-14-16-36(17-15-35)31(38)24(5)19-25-9-10-26(32)20-23(25)4/h8-11,18,20-21,24,30H,12-17,19H2,1-7H3,(H,33,37)/t24-,30+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells				Bioorg Med Chem 16: 5606-18 (2008) Article DOI: 10.1016/j.bmc.2008.03.072 BindingDB Entry DOI: 10.7270/Q2TX3F54
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149255 (3-((R)-2-Cyclopentyl-2-dimethylamino-ethyl)-1-(2,6...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](C2CCCC2)N(C)C)c1=O |wU:26.34,(6.63,1.74,;5.3,.97,;5.3,-.57,;6.65,-1.34,;6.63,-2.89,;5.3,-3.65,;3.97,-2.88,;3.97,-1.34,;2.64,-.57,;2.64,-3.64,;2.64,-5.16,;3.97,-5.93,;1.29,-5.96,;1.29,-7.5,;2.62,-8.26,;2.62,-9.81,;1.29,-10.58,;3.95,-10.58,;5.3,-9.81,;5.3,-8.26,;3.95,-7.47,;5.05,-6.39,;-.04,-5.18,;-.05,-6.68,;-.04,-3.62,;-1.37,-2.85,;-2.7,-3.62,;-2.7,-5.16,;-3.96,-6.07,;-3.48,-7.54,;-1.94,-7.54,;-1.46,-6.07,;-4.03,-2.85,;-5.36,-3.62,;-4.03,-1.31,;1.31,-2.85,;1.31,-1.31,)| Show InChI InChI=1S/C28H32F3N3O3/c1-17-25(19-11-7-14-24(37-4)26(19)31)27(35)34(16-23(32(2)3)18-9-5-6-10-18)28(36)33(17)15-20-21(29)12-8-13-22(20)30/h7-8,11-14,18,23H,5-6,9-10,15-16H2,1-4H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50162008 ((R)-1-(2-chloro-6-fluorobenzyl)-3-(2-amino-2-pheny...) Show SMILES Cc1c(-c2ccccc2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1Cl |r,wD:14.15,(32.48,-29.08,;31.15,-28.31,;31.15,-26.77,;32.48,-26,;33.81,-26.77,;35.14,-26,;35.14,-24.46,;33.8,-23.69,;32.47,-24.47,;31.13,-23.7,;29.82,-25.99,;29.82,-24.45,;28.49,-26.77,;27.15,-26.01,;25.82,-26.78,;25.83,-28.32,;24.49,-26.02,;24.49,-24.47,;23.16,-23.71,;21.82,-24.48,;21.83,-26.03,;23.17,-26.79,;28.49,-28.31,;27.16,-29.08,;29.82,-29.07,;29.82,-30.61,;31.15,-31.38,;32.47,-30.61,;31.13,-29.84,;33.81,-31.38,;33.81,-32.93,;32.48,-33.7,;31.14,-32.93,;29.81,-33.69,)| Show InChI InChI=1S/C26H22ClF2N3O2/c1-16-24(18-10-5-6-12-21(18)28)25(33)32(15-23(30)17-8-3-2-4-9-17)26(34)31(16)14-19-20(27)11-7-13-22(19)29/h2-13,23H,14-15,30H2,1H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.610	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50166450 ((R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-am...) Show SMILES COc1cccc(c1F)-c1cn(Cc2c(F)cccc2C(F)(F)F)c(=O)n(C[C@H](N)c2ccccc2)c1=O |r| Show InChI InChI=1S/C27H22F5N3O3/c1-38-23-12-5-9-17(24(23)29)18-13-34(14-19-20(27(30,31)32)10-6-11-21(19)28)26(37)35(25(18)36)15-22(33)16-7-3-2-4-8-16/h2-13,22H,14-15,33H2,1H3/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.640	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human GnRHR				Bioorg Med Chem Lett 18: 3301-5 (2008) Article DOI: 10.1016/j.bmcl.2008.04.036 BindingDB Entry DOI: 10.7270/Q2JD4WKM
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50166450 ((R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-am...) Show SMILES COc1cccc(c1F)-c1cn(Cc2c(F)cccc2C(F)(F)F)c(=O)n(C[C@H](N)c2ccccc2)c1=O |r| Show InChI InChI=1S/C27H22F5N3O3/c1-38-23-12-5-9-17(24(23)29)18-13-34(14-19-20(27(30,31)32)10-6-11-21(19)28)26(37)35(25(18)36)15-22(33)16-7-3-2-4-8-16/h2-13,22H,14-15,33H2,1H3/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.640	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation counting				J Med Chem 51: 7478-85 (2009) Article DOI: 10.1021/jm8006454 BindingDB Entry DOI: 10.7270/Q2S46RT8
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Mus musculus)	BDBM50221120 (1-((R)-1-(4-(2-((S)-1-(2-aminoethylamino)-3-methyl...) Show SMILES CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1Cl)N1CCCC1=O Show InChI InChI=1S/C30H40Cl2FN5O2/c1-20(2)17-26(35-11-10-34)23-5-3-6-25(33)29(23)36-13-15-37(16-14-36)30(40)27(38-12-4-7-28(38)39)18-21-8-9-22(31)19-24(21)32/h3,5-6,8-9,19-20,26-27,35H,4,7,10-18,34H2,1-2H3/t26-,27+/m0/s1	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.710	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to mouse MC4R				J Med Chem 50: 6356-66 (2007) Article DOI: 10.1021/jm701137s BindingDB Entry DOI: 10.7270/Q2P84BM9
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50261229 (1-{2-[(1S)-((2R)-Aminopropionamido)-2-methylpropyl...) Show SMILES COc1cc(Cl)ccc1C[C@@H](C)C(=O)N1CCN(CC1)c1ccc(Cl)cc1[C@@H](NC(=O)[C@@H](C)N)C(C)C |r| Show InChI InChI=1S/C28H38Cl2N4O3/c1-17(2)26(32-27(35)19(4)31)23-15-21(29)8-9-24(23)33-10-12-34(13-11-33)28(36)18(3)14-20-6-7-22(30)16-25(20)37-5/h6-9,15-19,26H,10-14,31H2,1-5H3,(H,32,35)/t18-,19-,26+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells				Bioorg Med Chem 16: 5606-18 (2008) Article DOI: 10.1016/j.bmc.2008.03.072 BindingDB Entry DOI: 10.7270/Q2TX3F54
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50274930 ((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2C(F)(F)F)c(=O)n(C[C@H](NCCCC([O-])=O)c2ccccc2)c1=O |r,wD:29.31,(30.28,-13.89,;28.95,-14.65,;27.62,-13.88,;27.62,-12.34,;26.28,-11.56,;24.95,-12.33,;24.95,-13.87,;26.28,-14.64,;26.27,-16.18,;23.62,-14.63,;23.62,-16.17,;24.95,-16.94,;22.29,-16.93,;22.29,-18.47,;23.62,-19.24,;24.95,-18.47,;26.27,-17.69,;26.28,-19.24,;26.28,-20.78,;24.95,-21.55,;23.62,-20.78,;22.28,-21.55,;20.94,-22.31,;23.04,-22.89,;21.52,-20.21,;20.96,-16.17,;19.63,-16.94,;20.96,-14.63,;19.63,-13.86,;18.29,-14.64,;18.3,-16.18,;16.97,-16.95,;16.97,-18.49,;15.64,-19.27,;15.64,-20.81,;14.31,-21.58,;16.98,-21.57,;16.96,-13.87,;16.95,-12.33,;15.62,-11.57,;14.28,-12.35,;14.29,-13.88,;15.63,-14.64,;22.29,-13.85,;22.29,-12.31,)| Show InChI InChI=1S/C32H30F5N3O5/c1-19-28(21-11-6-14-26(45-2)29(21)34)30(43)40(18-25(20-9-4-3-5-10-20)38-16-8-15-27(41)42)31(44)39(19)17-22-23(32(35,36)37)12-7-13-24(22)33/h3-7,9-14,25,38H,8,15-18H2,1-2H3,(H,41,42)/p-1/t25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation counting				J Med Chem 51: 7478-85 (2009) Article DOI: 10.1021/jm8006454 BindingDB Entry DOI: 10.7270/Q2S46RT8
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50221120 (1-((R)-1-(4-(2-((S)-1-(2-aminoethylamino)-3-methyl...) Show SMILES CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1Cl)N1CCCC1=O Show InChI InChI=1S/C30H40Cl2FN5O2/c1-20(2)17-26(35-11-10-34)23-5-3-6-25(33)29(23)36-13-15-37(16-14-36)30(40)27(38-12-4-7-28(38)39)18-21-8-9-22(31)19-24(21)32/h3,5-6,8-9,19-20,26-27,35H,4,7,10-18,34H2,1-2H3/t26-,27+/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cells				J Med Chem 50: 6356-66 (2007) Article DOI: 10.1021/jm701137s BindingDB Entry DOI: 10.7270/Q2P84BM9
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50166451 ((R)-1-(2-fluoro-6-(methylsulfonyl)benzyl)-3-(2-ami...) Show SMILES COc1cccc(c1F)-c1cn(Cc2c(F)cccc2S(C)(=O)=O)c(=O)n(C[C@H](N)c2ccccc2)c1=O |r| Show InChI InChI=1S/C27H25F2N3O5S/c1-37-23-12-6-10-18(25(23)29)19-14-31(15-20-21(28)11-7-13-24(20)38(2,35)36)27(34)32(26(19)33)16-22(30)17-8-4-3-5-9-17/h3-14,22H,15-16,30H2,1-2H3/t22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human GnRHR				Bioorg Med Chem Lett 18: 3301-5 (2008) Article DOI: 10.1016/j.bmcl.2008.04.036 BindingDB Entry DOI: 10.7270/Q2JD4WKM
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50261228 (1-{2-[(1S)-(Methylaminoacetamido)-2-methylpropyl]-...) Show SMILES CNCC(=O)N[C@@H](C(C)C)c1cc(Cl)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1OC |r| Show InChI InChI=1S/C28H38Cl2N4O3/c1-18(2)27(32-26(35)17-31-4)23-15-21(29)8-9-24(23)33-10-12-34(13-11-33)28(36)19(3)14-20-6-7-22(30)16-25(20)37-5/h6-9,15-16,18-19,27,31H,10-14,17H2,1-5H3,(H,32,35)/t19-,27+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells				Bioorg Med Chem 16: 5606-18 (2008) Article DOI: 10.1016/j.bmc.2008.03.072 BindingDB Entry DOI: 10.7270/Q2TX3F54
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50274931 ((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-chloro...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2Cl)c(=O)n(C[C@H](NCCCC(O)=O)c2ccccc2)c1=O |r,wD:26.28,(8.1,-10.47,;6.76,-11.23,;5.43,-10.46,;5.44,-8.92,;4.1,-8.14,;2.77,-8.91,;2.77,-10.45,;4.1,-11.22,;4.09,-12.76,;1.44,-11.21,;1.44,-12.75,;2.77,-13.52,;.11,-13.51,;.11,-15.05,;1.44,-15.82,;2.76,-15.05,;4.09,-14.27,;4.1,-15.81,;4.1,-17.36,;2.77,-18.13,;1.43,-17.36,;.1,-18.13,;-1.22,-12.75,;-2.55,-13.52,;-1.22,-11.21,;-2.56,-10.44,;-3.89,-11.22,;-3.88,-12.76,;-5.22,-13.53,;-5.21,-15.07,;-6.54,-15.84,;-6.54,-17.38,;-7.87,-18.16,;-5.2,-18.15,;-5.22,-10.45,;-5.23,-8.91,;-6.57,-8.14,;-7.9,-8.93,;-7.89,-10.46,;-6.56,-11.22,;.11,-10.43,;.11,-8.89,)| Show InChI InChI=1S/C31H30ClF2N3O5/c1-19-28(21-11-6-14-26(42-2)29(21)34)30(40)37(31(41)36(19)17-22-23(32)12-7-13-24(22)33)18-25(20-9-4-3-5-10-20)35-16-8-15-27(38)39/h3-7,9-14,25,35H,8,15-18H2,1-2H3,(H,38,39)/t25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation counting				J Med Chem 51: 7478-85 (2009) Article DOI: 10.1021/jm8006454 BindingDB Entry DOI: 10.7270/Q2S46RT8
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50166458 ((R)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-3-(2-am...) Show SMILES N[C@@H](Cn1c(=O)c(cn(Cc2c(F)cccc2C(F)(F)F)c1=O)-c1ccccc1Cl)c1ccccc1 |r| Show InChI InChI=1S/C26H20ClF4N3O2/c27-21-11-5-4-9-17(21)18-13-33(14-19-20(26(29,30)31)10-6-12-22(19)28)25(36)34(24(18)35)15-23(32)16-7-2-1-3-8-16/h1-13,23H,14-15,32H2/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human GnRHR				Bioorg Med Chem Lett 18: 3301-5 (2008) Article DOI: 10.1016/j.bmcl.2008.04.036 BindingDB Entry DOI: 10.7270/Q2JD4WKM
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50260759 ((R)-4-(2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-5...) Show SMILES COc1cccc(c1F)-c1cn(Cc2c(F)cccc2C(F)(F)F)c(=O)n(C[C@H](NCCCC(O)=O)c2ccccc2)c1=O |r| Show InChI InChI=1S/C31H28F5N3O5/c1-44-26-13-5-10-20(28(26)33)21-16-38(17-22-23(31(34,35)36)11-6-12-24(22)32)30(43)39(29(21)42)18-25(19-8-3-2-4-9-19)37-15-7-14-27(40)41/h2-6,8-13,16,25,37H,7,14-15,17-18H2,1H3,(H,40,41)/t25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation counting				J Med Chem 51: 7478-85 (2009) Article DOI: 10.1021/jm8006454 BindingDB Entry DOI: 10.7270/Q2S46RT8
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149263 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) Show SMILES CN[C@H](CC(C)C)Cn1c(=O)c(c(C)n(Cc2c(F)cccc2F)c1=O)-c1cccc(OC)c1F |wU:2.1,(3.53,-4.51,;4.86,-3.74,;6.19,-4.51,;6.19,-6.05,;4.86,-6.82,;3.53,-6.05,;4.85,-8.36,;7.54,-3.76,;8.87,-4.53,;10.2,-3.76,;10.2,-2.22,;11.53,-4.53,;11.53,-6.07,;12.86,-6.84,;10.2,-6.84,;10.2,-8.38,;11.53,-9.15,;12.86,-8.38,;13.94,-7.29,;14.19,-9.15,;14.19,-10.69,;12.86,-11.46,;11.53,-10.69,;10.18,-11.46,;8.87,-6.07,;7.52,-6.84,;12.86,-3.76,;14.19,-4.55,;15.54,-3.79,;15.55,-2.24,;14.19,-1.47,;14.19,.07,;15.54,.84,;12.86,-2.24,;11.53,-1.45,)| Show InChI InChI=1S/C26H30F3N3O3/c1-15(2)12-17(30-4)13-32-25(33)23(18-8-6-11-22(35-5)24(18)29)16(3)31(26(32)34)14-19-20(27)9-7-10-21(19)28/h6-11,15,17,30H,12-14H2,1-5H3/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149263 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) Show SMILES CN[C@H](CC(C)C)Cn1c(=O)c(c(C)n(Cc2c(F)cccc2F)c1=O)-c1cccc(OC)c1F |wU:2.1,(3.53,-4.51,;4.86,-3.74,;6.19,-4.51,;6.19,-6.05,;4.86,-6.82,;3.53,-6.05,;4.85,-8.36,;7.54,-3.76,;8.87,-4.53,;10.2,-3.76,;10.2,-2.22,;11.53,-4.53,;11.53,-6.07,;12.86,-6.84,;10.2,-6.84,;10.2,-8.38,;11.53,-9.15,;12.86,-8.38,;13.94,-7.29,;14.19,-9.15,;14.19,-10.69,;12.86,-11.46,;11.53,-10.69,;10.18,-11.46,;8.87,-6.07,;7.52,-6.84,;12.86,-3.76,;14.19,-4.55,;15.54,-3.79,;15.55,-2.24,;14.19,-1.47,;14.19,.07,;15.54,.84,;12.86,-2.24,;11.53,-1.45,)| Show InChI InChI=1S/C26H30F3N3O3/c1-15(2)12-17(30-4)13-32-25(33)23(18-8-6-11-22(35-5)24(18)29)16(3)31(26(32)34)14-19-20(27)9-7-10-21(19)28/h6-11,15,17,30H,12-14H2,1-5H3/t17-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50261231 (1-{2-[(1S)-(Azetidine-3-carboxamido)-2-methylpropy...) Show SMILES COc1cc(Cl)ccc1C[C@@H](C)C(=O)N1CCN(CC1)c1ccc(Cl)cc1[C@@H](NC(=O)C1CNC1)C(C)C |r| Show InChI InChI=1S/C29H38Cl2N4O3/c1-18(2)27(33-28(36)21-16-32-17-21)24-14-22(30)7-8-25(24)34-9-11-35(12-10-34)29(37)19(3)13-20-5-6-23(31)15-26(20)38-4/h5-8,14-15,18-19,21,27,32H,9-13,16-17H2,1-4H3,(H,33,36)/t19-,27+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells				Bioorg Med Chem 16: 5606-18 (2008) Article DOI: 10.1016/j.bmc.2008.03.072 BindingDB Entry DOI: 10.7270/Q2TX3F54
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50152188 ((4-Chloro-benzyl)-[3-(6-dimethylamino-4-methyl-pyr...) Show SMILES CCN(Cc1ccc(Cl)cc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.7,1.45,;4.67,.3,;3.17,.61,;2.68,2.07,;3.69,3.22,;3.2,4.68,;4.21,5.83,;5.75,5.52,;6.77,6.67,;6.23,4.05,;5.21,2.91,;2.15,-.54,;2.61,-1.99,;1.59,-3.15,;2.08,-4.6,;.1,-2.83,;-.39,-1.38,;-1.8,-.75,;-1.65,.79,;-2.8,1.8,;-.14,1.11,;.63,-.23,;-3.13,-1.52,;-3.13,-3.08,;-4.45,-3.85,;-5.79,-3.08,;-5.79,-1.54,;-4.45,-.75,;-4.46,.79,;-7.13,-3.85,;-8.46,-3.08,;-7.13,-5.39,)| Show InChI InChI=1S/C25H29ClN6/c1-7-31(15-19-8-10-20(26)11-9-19)23-13-17(3)28-25-24(18(4)29-32(23)25)21-14-27-22(30(5)6)12-16(21)2/h8-14H,7,15H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor				J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50166452 ((R)-1-(2-fluoro-6-(methylsulfonyl)benzyl)-3-(2-ami...) Show SMILES CS(=O)(=O)c1cccc(F)c1Cn1cc(-c2ccccc2Cl)c(=O)n(C[C@H](N)c2ccccc2)c1=O |r| Show InChI InChI=1S/C26H23ClFN3O4S/c1-36(34,35)24-13-7-12-22(28)20(24)15-30-14-19(18-10-5-6-11-21(18)27)25(32)31(26(30)33)16-23(29)17-8-3-2-4-9-17/h2-14,23H,15-16,29H2,1H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human GnRHR				Bioorg Med Chem Lett 18: 3301-5 (2008) Article DOI: 10.1016/j.bmcl.2008.04.036 BindingDB Entry DOI: 10.7270/Q2JD4WKM
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50071235 (CHEMBL65078 | Cyclopropylmethyl-[3-(2,4-dichloro-p...) Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1Cl |(17.18,-6.55,;17.15,-8.09,;15.79,-8.82,;15.75,-10.36,;17.06,-11.17,;17.01,-12.71,;18.31,-13.5,;15.65,-13.44,;14.4,-11.1,;14.35,-12.63,;12.98,-13.38,;12.93,-14.91,;11.67,-12.57,;11.72,-11.01,;10.61,-9.94,;11.28,-8.56,;10.55,-7.21,;12.81,-8.78,;13.09,-10.29,;9.11,-10.22,;8.1,-9.04,;6.59,-9.31,;6.08,-10.76,;4.57,-11.03,;7.07,-11.93,;8.59,-11.67,;9.57,-12.83,)| Show InChI InChI=1S/C21H24Cl2N4/c1-4-9-26(12-15-5-6-15)19-10-13(2)24-21-20(14(3)25-27(19)21)17-8-7-16(22)11-18(17)23/h7-8,10-11,15H,4-6,9,12H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor				J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50162003 (1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...) Show SMILES CN[C@@H](Cn1c(=O)c(c(C)n(Cc2c(F)cccc2F)c1=O)-c1cccc(OC)c1F)c1ccccc1 |wD:2.1,(-3.85,-2.39,;-3.85,-.85,;-3.85,.68,;-2.54,1.46,;-1.19,.69,;.15,1.49,;.15,3.03,;1.48,.69,;1.48,-.85,;2.8,-1.62,;.15,-1.59,;.15,-3.13,;1.48,-3.9,;2.8,-3.13,;1.45,-2.36,;4.14,-3.9,;4.14,-5.44,;2.8,-6.23,;1.48,-5.44,;.14,-6.23,;-1.19,-.85,;-2.51,-1.62,;2.8,1.46,;4.14,.68,;5.46,1.46,;5.48,2.99,;4.14,3.77,;4.14,5.31,;2.8,6.08,;2.8,2.99,;1.48,3.77,;-5.2,1.46,;-5.2,2.99,;-6.53,3.77,;-7.86,2.98,;-7.86,1.42,;-6.5,.68,)| Show InChI InChI=1S/C28H26F3N3O3/c1-17-25(19-11-7-14-24(37-3)26(19)31)27(35)34(16-23(32-2)18-9-5-4-6-10-18)28(36)33(17)15-20-21(29)12-8-13-22(20)30/h4-14,23,32H,15-16H2,1-3H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50054245 (5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...) Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50274929 ((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2,6-difl...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](NCCCC(O)=O)c2ccccc2)c1=O |r,wD:26.28,(8.92,-11.98,;7.58,-12.75,;6.25,-11.97,;6.26,-10.43,;4.91,-9.66,;3.58,-10.43,;3.58,-11.96,;4.91,-12.74,;4.91,-14.28,;2.25,-12.72,;2.25,-14.26,;3.59,-15.04,;.92,-15.03,;.92,-16.57,;2.26,-17.34,;3.58,-16.57,;4.91,-15.79,;4.91,-17.33,;4.92,-18.88,;3.58,-19.65,;2.25,-18.88,;.91,-19.64,;-.4,-14.26,;-1.74,-15.04,;-.4,-12.72,;-1.74,-11.96,;-3.07,-12.73,;-3.07,-14.27,;-4.4,-15.05,;-4.39,-16.59,;-5.73,-17.36,;-5.72,-18.9,;-7.05,-19.67,;-4.38,-19.67,;-4.41,-11.97,;-4.41,-10.43,;-5.75,-9.66,;-7.08,-10.44,;-7.07,-11.98,;-5.74,-12.74,;.92,-11.95,;.92,-10.41,)| Show InChI InChI=1S/C31H30F3N3O5/c1-19-28(21-11-6-14-26(42-2)29(21)34)30(40)37(31(41)36(19)17-22-23(32)12-7-13-24(22)33)18-25(20-9-4-3-5-10-20)35-16-8-15-27(38)39/h3-7,9-14,25,35H,8,15-18H2,1-2H3,(H,38,39)/t25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation counting				J Med Chem 51: 7478-85 (2009) Article DOI: 10.1021/jm8006454 BindingDB Entry DOI: 10.7270/Q2S46RT8
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50260759 ((R)-4-(2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-5...) Show SMILES COc1cccc(c1F)-c1cn(Cc2c(F)cccc2C(F)(F)F)c(=O)n(C[C@H](NCCCC(O)=O)c2ccccc2)c1=O |r| Show InChI InChI=1S/C31H28F5N3O5/c1-44-26-13-5-10-20(28(26)33)21-16-38(17-22-23(31(34,35)36)11-6-12-24(22)32)30(43)39(29(21)42)18-25(19-8-3-2-4-9-19)37-15-7-14-27(40)41/h2-6,8-13,16,25,37H,7,14-15,17-18H2,1H3,(H,40,41)/t25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity to human GnRHR				Bioorg Med Chem Lett 18: 3301-5 (2008) Article DOI: 10.1016/j.bmcl.2008.04.036 BindingDB Entry DOI: 10.7270/Q2JD4WKM
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50224179 (1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...) Show SMILES CC(C)[C@H](NC(=O)CCN(C)C)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1F |r| Show InChI InChI=1S/C30H42ClFN4O2/c1-20(2)29(33-28(37)11-12-34(5)6)25-17-21(3)7-10-27(25)35-13-15-36(16-14-35)30(38)22(4)18-23-8-9-24(31)19-26(23)32/h7-10,17,19-20,22,29H,11-16,18H2,1-6H3,(H,33,37)/t22-,29+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells				Bioorg Med Chem 16: 5606-18 (2008) Article DOI: 10.1016/j.bmc.2008.03.072 BindingDB Entry DOI: 10.7270/Q2TX3F54
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50152164 (CHEMBL366155 | [3-(6-Dimethylamino-2-methyl-pyridi...) Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ccc(nc1C)N(C)C |(3.88,5.71,;4.35,4.24,;3.34,3.1,;3.81,1.63,;5.33,1.32,;6.35,2.47,;7.85,2.16,;2.78,.48,;3.27,-.98,;2.25,-2.13,;2.73,-3.59,;.75,-1.8,;.26,-.36,;-1.14,.27,;-1,1.81,;-2.14,2.82,;.52,2.12,;1.29,.79,;-2.47,-.52,;-3.8,.26,;-5.13,-.52,;-5.13,-2.06,;-3.8,-2.83,;-2.47,-2.06,;-1.14,-2.83,;-6.48,-2.83,;-6.48,-4.37,;-7.81,-2.06,)| Show InChI InChI=1S/C22H32N6/c1-8-12-27(13-9-2)20-14-15(3)23-22-21(17(5)25-28(20)22)18-10-11-19(26(6)7)24-16(18)4/h10-11,14H,8-9,12-13H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor				J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50161500 ((R)-1-(2,6-difluorobenzyl)-3-(2-amino-2-phenylethy...) Show SMILES COc1cccc(c1)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)c2ccccc2)c1=O |r| Show InChI InChI=1S/C27H25F2N3O3/c1-17-25(19-10-6-11-20(14-19)35-2)26(33)32(16-24(30)18-8-4-3-5-9-18)27(34)31(17)15-21-22(28)12-7-13-23(21)29/h3-14,24H,15-16,30H2,1-2H3/t24-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50152183 (CHEMBL186033 | [3-(6-Dimethylamino-4-methyl-pyridi...) Show SMILES CCN(Cc1ccc(C)cc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.7,1.45,;4.67,.3,;3.17,.61,;2.68,2.07,;3.69,3.22,;3.2,4.68,;4.21,5.83,;5.75,5.52,;6.77,6.67,;6.23,4.05,;5.21,2.91,;2.15,-.54,;2.61,-1.99,;1.59,-3.15,;2.08,-4.6,;.1,-2.83,;-.39,-1.38,;-1.8,-.75,;-1.65,.79,;-2.8,1.8,;-.14,1.11,;.63,-.23,;-3.13,-1.52,;-3.13,-3.08,;-4.45,-3.85,;-5.79,-3.08,;-5.79,-1.54,;-4.45,-.75,;-4.46,.79,;-7.13,-3.85,;-8.46,-3.08,;-7.13,-5.39,)| Show InChI InChI=1S/C26H32N6/c1-8-31(16-21-11-9-17(2)10-12-21)24-14-19(4)28-26-25(20(5)29-32(24)26)22-15-27-23(30(6)7)13-18(22)3/h9-15H,8,16H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor				J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50152179 (CHEMBL185705 | [3-(6-Dimethylamino-4-methyl-pyridi...) Show SMILES CCN(Cc1cccc(C)c1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.79,1.42,;4.77,.27,;3.27,.6,;2.79,2.06,;3.81,3.22,;5.3,2.89,;6.34,4.04,;5.85,5.5,;4.33,5.81,;3.84,7.28,;3.32,4.67,;2.24,-.56,;2.72,-2.02,;1.68,-3.18,;2.18,-4.63,;.19,-2.86,;-.3,-1.4,;-1.7,-.78,;-1.54,.76,;-2.7,1.78,;-.04,1.09,;.73,-.26,;-3.03,-1.55,;-3.03,-3.09,;-4.36,-3.88,;-5.69,-3.09,;-5.69,-1.56,;-4.36,-.78,;-4.38,.76,;-7.03,-3.88,;-7.03,-5.42,;-8.36,-3.09,)| Show InChI InChI=1S/C26H32N6/c1-8-31(16-21-11-9-10-17(2)12-21)24-14-19(4)28-26-25(20(5)29-32(24)26)22-15-27-23(30(6)7)13-18(22)3/h9-15H,8,16H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor				J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50149259 (3-((S)-2-Cyclopentyl-2-dimethylamino-ethyl)-1-(2,6...) Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](C2CCCC2)N(C)C)c1=O |wD:26.34,(26.87,2.44,;25.54,1.67,;25.54,.13,;26.88,-.64,;26.87,-2.19,;25.54,-2.95,;24.21,-2.18,;24.21,-.64,;22.88,.13,;22.87,-2.94,;22.87,-4.47,;24.2,-5.24,;21.52,-5.26,;21.52,-6.8,;22.85,-7.56,;22.85,-9.11,;21.52,-9.88,;24.18,-9.88,;25.53,-9.11,;25.53,-7.56,;24.18,-6.79,;25.28,-5.69,;20.19,-4.48,;20.17,-5.94,;20.19,-2.92,;18.86,-2.15,;17.53,-2.92,;17.53,-4.47,;16.29,-5.37,;16.76,-6.84,;18.3,-6.84,;18.77,-5.38,;16.2,-2.15,;14.87,-2.92,;16.2,-.61,;21.54,-2.15,;21.55,-.61,)| Show InChI InChI=1S/C28H32F3N3O3/c1-17-25(19-11-7-14-24(37-4)26(19)31)27(35)34(16-23(32(2)3)18-9-5-6-10-18)28(36)33(17)15-20-21(29)12-8-13-22(20)30/h7-8,11-14,18,23H,5-6,9-10,15-16H2,1-4H3/t23-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Binding affinity towards human gonadotropin releasing hormone receptor using des-Gly10[125I-Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]GnRH as radioligand expresse...				J Med Chem 47: 3483-6 (2004) Article DOI: 10.1021/jm049791w BindingDB Entry DOI: 10.7270/Q2HT2NTX
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50152178 (CHEMBL361509 | [3-(6-Dimethylamino-4-methyl-pyridi...) Show SMILES CCN(Cc1ccccc1C)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.86,1.5,;4.84,.34,;3.33,.67,;2.85,2.13,;3.86,3.29,;5.37,2.96,;6.4,4.13,;5.91,5.58,;4.39,5.89,;3.37,4.74,;1.87,5.06,;2.3,-.49,;2.78,-1.94,;1.75,-3.09,;2.24,-4.56,;.26,-2.78,;-.23,-1.32,;-1.64,-.71,;-1.49,.84,;-2.64,1.86,;.02,1.16,;.79,-.17,;-2.97,-1.47,;-2.97,-3.02,;-4.3,-3.81,;-5.63,-3.02,;-5.63,-1.5,;-4.3,-.71,;-4.31,.84,;-6.98,-3.81,;-8.31,-3.02,;-6.98,-5.33,)| Show InChI InChI=1S/C26H32N6/c1-8-31(16-21-12-10-9-11-17(21)2)24-14-19(4)28-26-25(20(5)29-32(24)26)22-15-27-23(30(6)7)13-18(22)3/h9-15H,8,16H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor				J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50152176 ((3,4-Dichloro-benzyl)-[3-(6-dimethylamino-4-methyl...) Show SMILES CCN(Cc1ccc(Cl)c(Cl)c1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.58,1.23,;4.56,.09,;3.06,.39,;2.57,1.84,;3.59,3,;5.09,2.7,;6.12,3.84,;5.63,5.31,;6.66,6.46,;4.11,5.6,;3.62,7.06,;3.1,4.47,;2.03,-.77,;2.5,-2.2,;1.48,-3.37,;1.97,-4.81,;-.02,-3.06,;-.51,-1.59,;-1.91,-.96,;-1.75,.56,;-2.91,1.58,;-.25,.9,;.52,-.45,;-3.24,-1.75,;-3.24,-3.3,;-4.57,-4.07,;-5.9,-3.3,;-5.9,-1.76,;-4.57,-.96,;-4.57,.56,;-7.23,-4.07,;-8.58,-3.3,;-7.23,-5.61,)| Show InChI InChI=1S/C25H28Cl2N6/c1-7-32(14-18-8-9-20(26)21(27)12-18)23-11-16(3)29-25-24(17(4)30-33(23)25)19-13-28-22(31(5)6)10-15(19)2/h8-13H,7,14H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor				J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50226633 (CHEMBL393584 | N-((1R)-[2-{4-[2R-methyl-3-(2,4-dic...) Show SMILES CC(C)C[C@@H](NC(=O)CCN(C)C)c1ccc(C)nc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1Cl Show InChI InChI=1S/C30H43Cl2N5O2/c1-20(2)17-27(34-28(38)11-12-35(5)6)25-10-7-22(4)33-29(25)36-13-15-37(16-14-36)30(39)21(3)18-23-8-9-24(31)19-26(23)32/h7-10,19-21,27H,11-18H2,1-6H3,(H,34,38)/t21-,27-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDPMSH from human MC4R expressed in HEK293 cells				J Med Chem 50: 6356-66 (2007) Article DOI: 10.1021/jm701137s BindingDB Entry DOI: 10.7270/Q2P84BM9
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50152169 (CHEMBL189821 | Cyclopropylmethyl-[3-(6-dimethylami...) Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(3.74,5.38,;4.2,3.92,;3.2,2.77,;3.69,1.31,;5.18,.99,;6.21,2.14,;6.51,3.65,;7.67,2.61,;2.66,.16,;3.13,-1.31,;2.11,-2.46,;2.6,-3.92,;.61,-2.13,;.12,-.68,;-1.27,-.05,;-1.12,1.46,;-2.28,2.49,;.38,1.8,;1.15,.47,;-2.6,-.84,;-2.6,-2.39,;-3.93,-3.15,;-5.26,-2.39,;-5.26,-.84,;-3.93,-.05,;-3.94,1.46,;-6.6,-3.15,;-7.93,-2.39,;-6.6,-4.69,)| Show InChI InChI=1S/C23H32N6/c1-7-10-28(14-18-8-9-18)21-12-16(3)25-23-22(17(4)26-29(21)23)19-13-24-20(27(5)6)11-15(19)2/h11-13,18H,7-10,14H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor				J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50152173 (Butyl-[3-(6-dimethylamino-4-methyl-pyridin-3-yl)-2...) Show SMILES CCCCN(CC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(5.11,6.53,;4.07,5.37,;4.56,3.91,;3.55,2.75,;4.02,1.3,;5.51,.97,;6.56,2.14,;2.99,.14,;3.46,-1.31,;2.45,-2.46,;2.94,-3.93,;.96,-2.15,;.45,-.68,;-.93,-.05,;-.79,1.46,;-1.95,2.49,;.71,1.79,;1.49,.46,;-2.28,-.85,;-2.28,-2.39,;-3.59,-3.16,;-4.94,-2.39,;-4.94,-.85,;-3.59,-.08,;-3.61,1.46,;-6.27,-3.16,;-6.27,-4.7,;-7.6,-2.39,)| Show InChI InChI=1S/C22H32N6/c1-8-10-11-27(9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor				J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50410281 (CHEMBL2094063) Show SMILES CCCC[C@H](N(CCC)c1nc(-c2ccc(Cl)cc2OC)n(C)n1)c1ccc(F)cc1 |r| Show InChI InChI=1S/C24H30ClFN4O/c1-5-7-8-21(17-9-12-19(26)13-10-17)30(15-6-2)24-27-23(29(3)28-24)20-14-11-18(25)16-22(20)31-4/h9-14,16,21H,5-8,15H2,1-4H3/t21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Inc. Curated by ChEMBL					Assay Description Inhibition of [125I][Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells				J Med Chem 48: 1540-9 (2005) Article DOI: 10.1021/jm049339c BindingDB Entry DOI: 10.7270/Q29P32DN
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50224181 (1-{2-[(1S)-(3-dimethylaminopropionyl)amino-2-methy...) Show SMILES CC(C)[C@H](NC(=O)CCN(C)C)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H43ClN4O2/c1-21(2)29(32-28(36)13-14-33(5)6)26-19-22(3)7-12-27(26)34-15-17-35(18-16-34)30(37)23(4)20-24-8-10-25(31)11-9-24/h7-12,19,21,23,29H,13-18,20H2,1-6H3,(H,32,36)/t23-,29+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells				Bioorg Med Chem 16: 5606-18 (2008) Article DOI: 10.1016/j.bmc.2008.03.072 BindingDB Entry DOI: 10.7270/Q2TX3F54
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50224185 (1-{2-[(1S)-(methylaminoacetamido)-2-methylpropyl]-...) Show SMILES CNCC(=O)N[C@@H](C(C)C)c1cc(C)ccc1N1CCN(CC1)C(=O)[C@H](C)Cc1ccc(Cl)cc1F |r| Show InChI InChI=1S/C28H38ClFN4O2/c1-18(2)27(32-26(35)17-31-5)23-14-19(3)6-9-25(23)33-10-12-34(13-11-33)28(36)20(4)15-21-7-8-22(29)16-24(21)30/h6-9,14,16,18,20,27,31H,10-13,15,17H2,1-5H3,(H,32,35)/t20-,27+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells				Bioorg Med Chem 16: 5606-18 (2008) Article DOI: 10.1016/j.bmc.2008.03.072 BindingDB Entry DOI: 10.7270/Q2TX3F54
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50162005 (3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-chloro-phenyl)...) Show SMILES Cc1c(-c2ccccc2Cl)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1F |wD:14.15,(2.9,-1.34,;1.57,-.58,;1.57,.96,;2.9,1.73,;4.22,.95,;5.56,1.71,;5.56,3.27,;4.22,4.02,;2.9,3.27,;1.57,4.04,;.23,1.73,;.23,3.27,;-1.1,.96,;-2.43,1.73,;-3.76,.95,;-3.76,-.59,;-5.11,1.72,;-5.11,3.27,;-6.45,4.02,;-7.79,3.27,;-7.78,1.71,;-6.43,.94,;-1.1,-.58,;-2.43,-1.34,;.23,-1.34,;.23,-2.88,;1.57,-3.66,;1.57,-5.2,;.22,-5.97,;2.9,-5.97,;4.22,-5.2,;4.22,-3.65,;2.9,-2.88,;1.55,-2.09,)| Show InChI InChI=1S/C26H22ClF2N3O2/c1-16-24(18-10-5-6-11-20(18)27)25(33)32(15-23(30)17-8-3-2-4-9-17)26(34)31(16)14-19-21(28)12-7-13-22(19)29/h2-13,23H,14-15,30H2,1H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50168462 (2-(2,4-Dichloro-phenyl)-4-methyl-6-(1-propyl-butyl...) Show SMILES CCCC(CCC)N1CCc2nn(-c3ccc(Cl)cc3Cl)c3nc(C)cc1c23 Show InChI InChI=1S/C22H26Cl2N4/c1-4-6-16(7-5-2)27-11-10-18-21-20(27)12-14(3)25-22(21)28(26-18)19-9-8-15(23)13-17(19)24/h8-9,12-13,16H,4-7,10-11H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Inhibition of [125I]sauvagine binding to corticotropin releasing factor receptor 1 expressed in LtK- cells				J Med Chem 48: 4100-10 (2005) Article DOI: 10.1021/jm050070m BindingDB Entry DOI: 10.7270/Q2ZK5HGJ
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50152170 (Benzyl-butyl-[3-(6-dimethylamino-4-methyl-pyridin-...) Show SMILES CCCCN(Cc1ccccc1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(6.96,-2.52,;6.47,-1.06,;4.96,-.75,;4.48,.72,;2.97,1.03,;2.48,2.49,;3.51,3.66,;5.02,3.33,;6.03,4.47,;5.55,5.92,;4.04,6.25,;3.02,5.09,;1.95,-.12,;2.43,-1.59,;1.4,-2.73,;1.88,-4.2,;-.11,-2.41,;-.58,-.96,;-1.98,-.33,;-1.84,1.19,;-2.99,2.22,;-.33,1.52,;.44,.19,;-3.33,-1.12,;-3.33,-2.66,;-4.66,-3.43,;-5.99,-2.66,;-5.99,-1.12,;-4.66,-.35,;-4.66,1.19,;-7.32,-3.43,;-8.65,-2.66,;-7.32,-4.97,)| Show InChI InChI=1S/C27H34N6/c1-7-8-14-32(18-22-12-10-9-11-13-22)25-16-20(3)29-27-26(21(4)30-33(25)27)23-17-28-24(31(5)6)15-19(23)2/h9-13,15-17H,7-8,14,18H2,1-6H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Inhibition of [125I]-o-CRF binding to CHO cells expressing human CRF1 receptor				J Med Chem 47: 4787-98 (2004) Article DOI: 10.1021/jm040058e BindingDB Entry DOI: 10.7270/Q2N29WDR
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50162014 (3-((R)-2-Amino-2-phenyl-ethyl)-1-(2,6-difluoro-ben...) Show SMILES Cc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@H](N)c2ccccc2)c1=O |wD:25.27,(4.09,5.41,;4.09,3.87,;5.44,3.1,;5.44,1.56,;4.09,.79,;2.76,1.58,;2.76,3.1,;1.45,3.87,;1.45,.81,;1.45,-.73,;2.76,-1.5,;.1,-1.5,;.1,-3.04,;1.45,-3.81,;2.76,-3.02,;1.43,-2.25,;4.09,-3.79,;4.09,-5.35,;2.76,-6.12,;1.45,-5.35,;.1,-6.12,;-1.23,-.73,;-2.54,-1.5,;-1.23,.81,;-2.54,1.58,;-3.89,.79,;-3.89,-.75,;-5.22,1.56,;-5.22,3.1,;-6.55,3.87,;-7.89,3.1,;-7.88,1.56,;-6.53,.79,;.1,1.58,;.1,3.12,)| Show InChI InChI=1S/C27H24F3N3O2/c1-16-8-6-11-19(25(16)30)24-17(2)32(14-20-21(28)12-7-13-22(20)29)27(35)33(26(24)34)15-23(31)18-9-4-3-5-10-18/h3-13,23H,14-15,31H2,1-2H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50162023 (3-((R)-2-Amino-2-phenyl-ethyl)-5-(2-fluoro-phenyl)...) Show SMILES Cc1c(-c2ccccc2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1ccccc1C(F)(F)F |wD:14.15,(3.73,-.86,;2.39,-.1,;2.39,1.45,;3.73,2.21,;5.04,1.42,;6.38,2.19,;6.38,3.73,;5.04,4.5,;3.72,3.73,;2.39,4.52,;1.05,2.21,;1.05,3.77,;-.27,1.45,;-1.61,2.21,;-2.94,1.42,;-2.94,-.1,;-4.26,2.21,;-4.26,3.73,;-5.6,4.5,;-6.95,3.73,;-6.92,2.19,;-5.6,1.42,;-.27,-.1,;-1.61,-.86,;1.05,-.86,;1.05,-2.4,;-.27,-3.17,;-1.61,-2.39,;-2.94,-3.15,;-2.94,-4.7,;-1.6,-5.46,;-.27,-4.7,;1.07,-5.46,;2.29,-6.16,;1.34,-7.05,;2.57,-4.88,)| Show InChI InChI=1S/C27H23F4N3O2/c1-17-24(20-12-6-8-14-22(20)28)25(35)34(16-23(32)18-9-3-2-4-10-18)26(36)33(17)15-19-11-5-7-13-21(19)27(29,30)31/h2-14,23H,15-16,32H2,1H3/t23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Binding affinity for Human gonadotropin-releasing hormone receptor				J Med Chem 48: 1169-78 (2005) Article DOI: 10.1021/jm049218c BindingDB Entry DOI: 10.7270/Q2MK6CD8
					More data for this Ligand-Target Pair
Melanocortin receptor 4 (Homo sapiens (Human))	BDBM50261196 (1-{2-[(1S)-(3-Azetidinylcarboxamido)-2-methylpropy...) Show SMILES COc1cc(Cl)ccc1C[C@@H](C)C(=O)N1CCN(CC1)c1c(F)cccc1[C@@H](NC(=O)C1CNC1)C(C)C |r| Show InChI InChI=1S/C29H38ClFN4O3/c1-18(2)26(33-28(36)21-16-32-17-21)23-6-5-7-24(31)27(23)34-10-12-35(13-11-34)29(37)19(3)14-20-8-9-22(30)15-25(20)38-4/h5-9,15,18-19,21,26,32H,10-14,16-17H2,1-4H3,(H,33,36)/t19-,26+/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]NDP-MSH from human MC4R expressed in HEK293 cells				Bioorg Med Chem 16: 5606-18 (2008) Article DOI: 10.1016/j.bmc.2008.03.072 BindingDB Entry DOI: 10.7270/Q2TX3F54
					More data for this Ligand-Target Pair
Corticotropin-releasing factor receptor 1 (Homo sapiens (Human))	BDBM50074501 (Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-ph...) Show SMILES CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c1c(C)cc(C)cc1C |(4.9,1.82,;3.57,2.56,;2.24,1.79,;.91,2.55,;-.44,1.78,;-1.76,2.55,;-3.1,1.78,;-.42,.25,;-1.75,-.52,;-1.75,-2.06,;-3.08,-2.83,;-.42,-2.83,;.91,-2.06,;2.38,-2.54,;3.31,-1.29,;4.85,-1.29,;2.38,-.03,;2.86,1.43,;.91,-.52,;2.86,-4.02,;4.37,-4.33,;5.39,-3.17,;4.85,-5.78,;3.82,-6.93,;4.31,-8.4,;2.32,-6.61,;1.84,-5.14,;.33,-4.82,)| Show InChI InChI=1S/C24H34N4/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5/h13-14H,9-12H2,1-8H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences Curated by ChEMBL					Assay Description Inhibition of [125I]sauvagine binding to corticotropin releasing factor receptor 1 expressed in LtK- cells				J Med Chem 48: 4100-10 (2005) Article DOI: 10.1021/jm050070m BindingDB Entry DOI: 10.7270/Q2ZK5HGJ
					More data for this Ligand-Target Pair

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