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TargetMelanocortin receptor 4
LigandBDBM50261229
Substrate/Competitorn/a
Meas. Tech.ChEMBL_533293 (CHEMBL973312)
Ki 0.800000±n/a nM
Citation Chen, CTucci, FCJiang, WTran, JAFleck, BAHoare, SRWen, JChen, TJohns, MMarkison, SFoster, ACMarinkovic, DChen, CWArellano, MHarman, JSaunders, JBozigian, HMarks, D Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists. Bioorg Med Chem16:5606-18 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanocortin receptor 4
Name:Melanocortin receptor 4
Synonyms:MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:Enzyme
Mol. Mass.:36949.50
Organism:Homo sapiens (Human)
Description:P32245
Residue:332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50261229
n/a
NameBDBM50261229
Synonyms:1-{2-[(1S)-((2R)-Aminopropionamido)-2-methylpropyl]-4-chlorophenyl}-4-[(2R)-methyl-3-(2-methoxy-4-dichlorophenyl)propionyl]piperazine | CHEMBL467587
TypeSmall organic molecule
Emp. Form.C28H38Cl2N4O3
Mol. Mass.549.532
SMILESCOc1cc(Cl)ccc1C[C@@H](C)C(=O)N1CCN(CC1)c1ccc(Cl)cc1[C@@H](NC(=O)[C@@H](C)N)C(C)C |r|
Structure
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