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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50149653 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_303525 (CHEMBL839639) | ||
| Ki | 85±n/a nM | ||
| Citation |  Chen, C; Wilcoxen, KM; Huang, CQ; Xie, YF; McCarthy, JR; Webb, TR; Zhu, YF; Saunders, J; Liu, XJ; Chen, TK; Bozigian, H; Grigoriadis, DE Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists. J Med Chem47:4787-98 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50149653 | |||
| n/a | |||
| Name | BDBM50149653 | ||
| Synonyms: | CHEMBL182595 | [3-(5-Amino-3-methyl-pyridin-2-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-dipropyl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H28N6 | ||
| Mol. Mass. | 352.4765 | ||
| SMILES | CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1ncc(N)cc1C |(6.99,-.28,;5.47,-.05,;4.89,1.35,;3.35,1.56,;2.76,2.98,;3.7,4.2,;3.11,5.64,;2.41,.33,;3,-1.08,;2.06,-2.31,;2.65,-3.74,;.55,-2.1,;-.04,-.68,;-1.49,-.17,;-1.45,1.37,;-2.65,2.3,;.03,1.8,;.9,.53,;-2.89,-.84,;-2.89,-2.39,;-4.22,-3.18,;-5.55,-2.39,;-6.88,-3.18,;-5.55,-.85,;-4.22,-.05,;-4.23,1.46,)| | ||
| Structure | 
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