Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50152181 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_303525 (CHEMBL839639) | ||
| Ki | 24±n/a nM | ||
| Citation |  Chen, C; Wilcoxen, KM; Huang, CQ; Xie, YF; McCarthy, JR; Webb, TR; Zhu, YF; Saunders, J; Liu, XJ; Chen, TK; Bozigian, H; Grigoriadis, DE Design of 2,5-dimethyl-3-(6-dimethyl-4-methylpyridin-3-yl)-7-dipropylaminopyrazolo[1,5-a]pyrimidine (NBI 30775/R121919) and structure--activity relationships of a series of potent and orally active corticotropin-releasing factor receptor antagonists. J Med Chem47:4787-98 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM50152181 | |||
| n/a | |||
| Name | BDBM50152181 | ||
| Synonyms: | CHEMBL364214 | [3-(6-Dimethylamino-4-methyl-pyridin-3-yl)-2,5-dimethyl-pyrazolo[1,5-a]pyrimidin-7-yl]-(3-methoxy-benzyl)-propyl-amine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H34N6O | ||
| Mol. Mass. | 458.5985 | ||
| SMILES | CCCN(Cc1cccc(OC)c1)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C |(6.44,-1.62,;4.93,-1.31,;4.45,.16,;2.93,.47,;2.46,1.93,;3.47,3.09,;4.99,2.77,;6.02,3.92,;5.53,5.37,;4.01,5.7,;3.52,7.15,;4.54,8.3,;2.98,4.54,;1.9,-.69,;2.39,-2.15,;1.36,-3.3,;1.86,-4.77,;-.13,-2.98,;-.62,-1.52,;-2.03,-.9,;-1.89,.63,;-3.03,1.66,;-.37,.96,;.41,-.37,;-3.36,-1.68,;-3.36,-3.23,;-4.69,-4,;-6.02,-3.23,;-6.02,-1.68,;-4.69,-.91,;-4.72,.63,;-7.38,-4,;-8.71,-3.23,;-7.38,-5.54,)| | ||
| Structure | 
| ||